N-phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agents

Bioorganic & Medicinal Chemistry
Lidia MatesicKara L Vine

Abstract

A range of N-phenethyl, N-phenacyl, and N-(1- and 2-naphthylmethyl) derivatives of 5,7-dibromoisatin 2 were prepared by N-alkylation reactions. Their activity against human monocyte-like histiocytic lymphoma (U937), leukemia (Jurkat), and breast carcinoma (MDA-MB-231) cell lines was assessed. The results allowed further development of structure-activity relationships. The compound 5,7-dibromo-N-(1-naphthylmethyl)-1H-indole-2,3-dione 5a was the most potent against U937 cells with an IC(50) value of 0.19 microM.

Citations

Oct 12, 2012·Journal of Molecular Modeling·Ramin MiriMohammad K Mohammadi
Nov 15, 2011·Archives of Pharmacal Research·Azza T TaherEman M Ahmed
Apr 28, 2011·Acta Crystallographica. Section E, Structure Reports Online·Weiyao WuZhichang Xiao
Dec 27, 2011·Acta Crystallographica. Section E, Structure Reports Online·Hua-Quan LiuPing-Kai Ou-Yang
Jan 20, 2012·Acta Crystallographica. Section E, Structure Reports Online·Hua Quan LiuPing Kai Ou-Yang
Jun 1, 2012·Chemistry Central Journal·Tarek Aboul-FadlHatem A Abdel-Aziz
Mar 16, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ahmed T A BoraeiHazem A Ghabbour
May 6, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Pramod K SharmaVirinder S Parmar
May 16, 2015·Beilstein Journal of Organic Chemistry·Alireza ShakooriPaul A Keller
Jul 18, 2014·Drug Discoveries & Therapeutics·Pengzhan LiGuisen Zhao
Jan 1, 2014·Medicinal Chemistry Research : an International Journal for Rapid Communications on Design and Mechanisms of Action of Biologically Active Agents·Sriramoju Bharath KumarDarmarajan Sriram
Aug 1, 2018·ACS Chemical Biology·Shinya TashiroKouhei Tsumoto
Apr 10, 2019·Biochemistry·Cale C StreeterSteven M Firestine
Sep 18, 2021·SAR and QSAR in Environmental Research·K SahinS Durdagi
Sep 26, 2020·Current Organic Synthesis·Garima ChauhanShaik Khasimbi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.