PMID: 8590778Aug 1, 1995Paper

N-ras and p53 gene mutations are very rare events in multiple myeloma

International Journal of Hematology
Y YasugaN Aokia

Abstract

The frequencies of p53 and N-ras gene mutations were examined in multiple myeloma. DNA samples of 45 cases of multiple myeloma were obtained from stored bone marrow smears. All samples were analyzed for the N-ras gene at codon 12 by the allele specific restriction analysis method and at codon 61 by direct sequencing. DNA was screened for mutations by single-strand conformation polymorphism analysis for the p53 gene in exons 5 to 8. DNA fragments showing an altered electrophoretic pattern were further studied by direct sequencing to confirm the mutations. Ras mutations were found in two cases at codon 61 (4.4%). A point mutation of the p53 gene was detected in one of 45 cases (2.2%). These 3 cases with mutations were in an advanced stage. In conclusion, N-ras and p53 gene mutations may occur at a late stage of multiple myeloma, but the frequencies of the mutations are very low.

Citations

Feb 1, 1997·Molecular Pathology : MP·R G OwenG J Morgan
Aug 29, 1998·British Journal of Haematology·C SakashitaS Hirosawa
Dec 3, 2005·Leukemia & Lymphoma·Manoela M OrtegaCarmen S P Lima
Jul 1, 1997·Scandinavian Journal of Clinical and Laboratory Investigation·H OllikainenK Pulkki
May 17, 2007·Srpski arhiv za celokupno lekarstvo·Olivera MarkovićMilica Colović
Jun 27, 2007·British Journal of Haematology·Orly Weizer-SternGideon Rechavi
Dec 6, 2000·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N G KastrinakisC Kittas
Feb 1, 1997·Hematology/oncology Clinics of North America·R FeinmanG Tricot

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