N-rich protein (NRP)-mediated cell death signaling: a new branch of the ER stress response with implications for plant biotechnology.

Plant Signaling & Behavior
Pedro A B Reis, Elizabeth P B Fontes

Abstract

Upon disruption of ER homeostasis, plant cells activate at least two branches of the unfolded protein response (UPR) through IRE1-like and ATAF6-like transducers, resulting in the upregulation of ER-resident molecular chaperones and the activation of the ER-associated degradation protein system. Here, we discuss a new ER stress response pathway in plants that is associated with an osmotic stress response in transducing a cell death signal. Both ER and osmotic stress induce the expression of the novel transcription factor GmERD15, which binds and activates N-rich protein (NRP) promoters to induce NRP expression and cause the upregulation of GmNAC6, an effector of the cell death response. In contrast to this activation mechanism, the ER-resident molecular chaperone binding protein (BiP) attenuates the propagation of the cell death signal by modulating the expression and activity of components of the ER and osmotic stress-induced NRP-mediated cell death signaling. This interaction attenuates dehydration-induced cell death and promotes a better adaptation of BiP-overexpressing transgenic lines to drought.

References

Dec 1, 1994·Plant Physiology·T KiyosueK Shinozaki
May 28, 1998·The Journal of Biological Chemistry·H LiuJ L Stevens
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Shiyu WangNina Fedoroff
Jun 15, 2007·Nature Reviews. Molecular Cell Biology·David Ron, Peter Walter
Nov 21, 2007·Seminars in Cell & Developmental Biology·Jyoti D Malhotra, Randal J Kaufman
Nov 27, 2007·BMC Genomics·André S T IrsiglerElizabeth P B Fontes
Oct 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Hongbo GaoRobert M Larkin
Apr 13, 2011·Proceedings of the National Academy of Sciences of the United States of America·Yan DengStephen H Howell
Jul 2, 2011·Biological Research·Adrian A Moreno, Ariel Orellana
Sep 15, 2011·The Plant Journal : for Cell and Molecular Biology·Yani Chen, Federica Brandizzi
Nov 5, 2011·The Plant Journal : for Cell and Molecular Biology·Shimpei HayashiFumio Takaiwa

❮ Previous
Next ❯

Citations

Dec 10, 2013·Plant Physiology·Humberto H CarvalhoElizabeth P B Fontes
Oct 23, 2013·Proceedings of the National Academy of Sciences of the United States of America·Giselle C MendesElizabeth P B Fontes
Jun 14, 2014·Frontiers in Plant Science·Brett WilliamsMartin B Dickman
Jan 25, 2020·The Plant Journal : for Cell and Molecular Biology·Inès BeaugelinMichel Havaux
Apr 9, 2019·Physiology and Molecular Biology of Plants : an International Journal of Functional Plant Biology·Flaviane Silva CoutinhoHumberto Josué de Oliveira Ramos
Dec 18, 2020·Frontiers in Genetics·Dalton O FerreiraElizabeth P B Fontes
Feb 9, 2021·Plant Physiology and Biochemistry : PPB·Navpreet Kaur, Pramod Kaitheri Kandoth
Sep 30, 2020·Molecular Plant·Stefano D'AlessandroMichel Havaux
Nov 2, 2021·Plant, Cell & Environment·Iana Pedro Silva QuadrosRenildes L F Fontes

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.