N-terminal pro B-type natriuretic peptide and the evaluation of cardiac dysfunction and severity of disease in cirrhotic patients.

Yonsei Medical Journal
Jeong Joo WooSoon Pyo Hong

Abstract

Cardiac dysfunction and hyperdynamic systemic circulation may be present in patients with cirrhosis. The purpose of this study was to identify relations between plasma levels of N-terminal-proBNP (NT-proBNP), reflecting early ventricular dysfunction, and the severity of liver disease and cardiac dysfunction in cirrhotic patients. Sixty-three cirrhotic patients and 15 controls (group 1) were enrolled in this study. Plasma levels of NT-proBNP were determined in echocardiographically examined patients, which were allocated to 1 of 3 groups according to Child-Pugh classification or into 2 groups, i.e., a compensated group without ascites (group 2) and decompensated group with ascites (group 3). Plasma NT-proBNP levels were significantly higher in cirrhotic patients (groups 2 and 3) than in age-matched controls (155.9 and 198.3 vs. 40.3 pg/mL, respectively, p < 0.05). NT-proBNP levels were significantly increased in Child class C patients than in classes B and A (250.0 vs. 168.6 and 119.6 pg/mL, respectively, p < 0.05). Left atrial dimension, wall thickness of left ventricle, and EF or E/E' were significantly increased, and EDT was prolonged in cirrhotic patients than in controls. Increased LVMI and decreased E/A ratio were noted in...Continue Reading

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Citations

Sep 3, 2013·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Pierpaolo PellicoriManuela Merli
Jan 29, 2011·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Fu-Rong SunBing Chang
Jun 13, 2015·Journal of Cardiovascular Medicine·Anna LicataCalogero Camma'
Apr 16, 2015·European Journal of Gastroenterology & Hepatology·Axel JosefssonEvangelos Kalaitzakis
Jul 12, 2018·Clinical and Molecular Hepatology·UNKNOWN Korean Association for the Study of the Liver (KASL)
Aug 28, 2018·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Soung Won Jeong
Jun 10, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Prasanna K SanthekadurArun J Sanyal

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