N-terminal pro-brain natriuretic peptide and the timing, extent and mortality in ST elevation myocardial infarction.

The Canadian Journal of Cardiology
Justin A EzekowitzPaul W Armstrong

Abstract

While natriuretic peptides have demonstrated diagnostic and prognostic potential in cardiac disorders, little is known about their relationship with the onset and quantification of myocardial infarction. The relationship of serial N-terminal pro-brain natriuretic peptide (NT-proBNP) with duration from symptom onset, infarct size and prognosis in ST elevation myocardial infarction (STEMI) patients treated with primary percutaneous intervention was examined. Three hundred thirty-one STEMI patients in the COMplement inhibition in Myocardial infarction treated with Angioplasty (COMMA) trial, which evaluated pexelizumab versus placebo, were studied. NT-proBNP (pg/mL) was measured at randomization, 24 h and 72 h; creatine kinase-MB area under the curve was measured at 72 h; and QRS score was assessed at discharge. Prognosis was ascertained from the 90-day composite clinical outcome of death, shock, stroke and congestive heart failure. Multivariate logistical regression was used to adjust for baseline characteristics for models at randomization, 24 h and 72 h. NT-proBNP was higher in patients with longer time from symptom onset (P<0.001) and correlated with measures of infarct size, including the area under the curve (P<0.001) and QRS...Continue Reading

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Citations

Sep 21, 2010·Internal and Emergency Medicine·Alberto PalazzuoliRanuccio Nuti
Jul 30, 2011·Future Cardiology·Jonathan W Waks, Benjamin M Scirica
Dec 27, 2018·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Enrico FabrisArnoud W J van 't Hof
Dec 22, 2006·European Journal of Clinical Investigation·V J Karthikeyan, G Y H Lip
May 10, 2007·Canadian Journal of Physiology and Pharmacology·Justin A EzekowitzPaul W Armstrong
Dec 13, 2016·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·D A A M SchellingsA Adiyaman

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