N-terminal pro-brain natriuretic peptide levels had an independent and added ability in the evaluation of all-cause mortality in older Chinese patients with atrial fibrillation

BMC Geriatrics
Shihui FuLeiming Luo

Abstract

Atrial fibrillation (AF) is the most common arrhythmia and has increased prevalence in older patients, leading to poor prognosis for these patients. There is a need for a biomarker or a model of prognostic evaluation in older patients with AF, especially in China. CHADS2 and CHA2DS2VASc scores have been applied to evaluate their prognosis in patients with AF. This analysis was designed to examine whether N-terminal pro-brain natriuretic peptide (NT-proBNP) levels significantly improved the evaluation of all-cause mortality in older Chinese patients with AF when added to CHADS2 and CHA2DS2VASc scores. There were 219 older patients with AF, and follow-up was 100% complete over an average of 1.11 years. Cox regression analysis was applied to determine the variables independently associated with all-cause mortality. Median age was 85 years, and all-cause mortality was 24.2% (53 patients). Plasma NT-proBNP levels were significantly associated with all-cause mortality in univariate [hazard ratio (HR): 1.842; 95% confidence interval (CI): 1.530-2.218] and multivariate (HR: 1.377; 95% CI: 1.063-1.785) Cox regression analyses and had significantly higher c-statistic (0.771; 95% CI: 0.698-0.845) than CHADS2 (0.639; 95% CI: 0.552-0.726) a...Continue Reading

References

Sep 1, 1989·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·N B SchillerI Schnittger
Sep 22, 2006·Journal of the American Society of Nephrology : JASN·Ying-Chun MaHai-Yan Wang
Feb 7, 2013·European Heart Journal·Ziad HijaziLars Wallentin
Nov 22, 2016·ESC Heart Failure·Akiomi YoshihisaYasuchika Takeishi
Jan 28, 2017·Seminars in Thrombosis and Hemostasis·Farhan Shahid, Gregory Y H Lip

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Citations

Feb 1, 2020·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Alireza Sepehri ShamlooArash Arya
Nov 11, 2020·Clinical and Experimental Pharmacology & Physiology·Hong DuHuiyu Shao

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Software Mentioned

Statistical Package for Social Sciences
MedCalc
ARISTOTLE

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