N-Terminal Pro-Brain Natriuretic Peptide (NT-proBNP) and Risk of Hypertension in the Atherosclerosis Risk in Communities (ARIC) Study

American Journal of Hypertension
Julie K BowerElizabeth Selvin

Abstract

Brain natriuretic peptide (BNP) is released by the heart in response to ventricular and auricular wall stress. Release of BNP is traditionally considered part of the body's protective mechanism against pressure overload by inducing vasodilatation and diuresis. More recent evidence demonstrates that BNP also promotes vessel wall stress and preliminary studies suggest that chronic increased levels may increase risk of hypertension. This study aimed to evaluate the prospective association of N-terminal BNP (NT-proBNP), a cleavage product of BNP, with risk of hypertension in the Atherosclerosis Risk in Communities cohort study. We conducted a prospective analysis of 3,798 middle-aged participants in the ARIC study without hypertension at baseline (1996-1998). Using Cox proportional hazards models, we characterized the association between NT-proBNP at baseline and newly diagnosed hypertension for a maximum of 14 years of follow-up (median = 9 years). We observed 2,113 new hypertension cases over the follow-up period. Higher baseline NT-proBNP was independently associated with an increased risk of hypertension. Adjusted hazard ratios for incident hypertension in the highest quartile compared to the lowest quartile of NT-proBNP at bas...Continue Reading

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Citations

Jul 24, 2018·The Journal of Clinical Hypertension·Tetsuya TakahashiMasafumi Watanabe
Jun 25, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Unal MutluM Kamran Ikram
Dec 17, 2019·Journal of the American Heart Association·Wendy YingErin D Michos
May 20, 2020·Annals of Internal Medicine·Stephen P JuraschekKenneth J Mukamal
Jun 12, 2018·Circulation Journal : Official Journal of the Japanese Circulation Society·Michihiro SatohTakayoshi Ohkubo
Dec 31, 2020·American Journal of Hypertension·Charles D NicoliMary Cushman
Mar 16, 2017·Open Access Macedonian Journal of Medical Sciences·Alexandr Borisovich MarchenkoAnar Akyilbekovna Turmukhambetova
May 29, 2021·Journal of the American College of Cardiology·Stephen P JuraschekKenneth J Mukamal

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