N-terminal pro-brain natriuretic peptide on admission in patients with acute myocardial infarction and correlation with scintigraphic infarct size, efficacy of reperfusion, and prognosis

The American Journal of Cardiology
Gjin NdrepepaAdnan Kastrati

Abstract

We investigated whether N-terminal pro-brain natriuretic peptide (NT-pro-BNP) that was measured on admission in patients with acute myocardial infarction (AMI) predicts the efficacy of reperfusion or whether NT-pro-BNP provides prognostic information independent of infarct size as estimated by single-photon emission computed tomographic scintigraphy. The study included 174 patients with ST-segment elevation AMI who were admitted within 24 hours of pain onset. NT-pro-BNP level was measured on admission. Paired scintigraphic studies (before and 7 to 14 days after reperfusion) were performed to assess infarct size and define myocardial salvage. One-year clinical follow-up was assessed. Patients were categorized into the high NT-pro-BNP group (57 patients in the upper tertile of NT-pro-BNP) and low NT-pro-BNP group (117 patients in the middle and lower tertiles of NT-pro-BNP). Initial median perfusion defect was 35.0% (interquartile rage 20.0 to 53.0%) of the left ventricle in the high NT-pro-BNP group versus 19.0% (interquartile range 10.0 to 32.2) of the left ventricle in the low NT-pro-BNP group (p <0.001). Median salvage index was 0.36 (interquartile range 0.16 to 0.86) in the high NT-pro-BNP group versus 0.53 (interquartile ra...Continue Reading

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Citations

Aug 15, 2012·Critical Care : the Official Journal of the Critical Care Forum·René P AndriéJörg O Schwab
Jul 30, 2011·Future Cardiology·Jonathan W Waks, Benjamin M Scirica
May 10, 2007·Canadian Journal of Physiology and Pharmacology·Justin A EzekowitzPaul W Armstrong
Feb 22, 2012·International Journal of Cardiology·Sally J Aldous
Nov 3, 2006·Annales de cardiologie et d'angéiologie·A Ben HalimaS Kachboura
Jun 20, 2020·Journal of the American Heart Association·Jay S ShavadiaPaul W Armstrong

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