PMID: 2493268Feb 23, 1989Paper

N-terminal sequence extension in the glycosylated forms of human pancreatic stone protein. The 5-oxoproline N-terminal chain is O-glycosylated on the 5th amino acid residue

Biochimica Et Biophysica Acta
A de CaroM Rovery

Abstract

The pancreatic stone protein isolated from human calculi (PSP) derives from the immunoreactive protein forms detected in human pancreatic juice (PSP S2-5) through the tryptic cleavage of the Arg-11-Ile-12 bond. Among the eleven amino acids of the PSP S2-5 N-terminal extension Z-E-A-Q-T-E-L-P-Q-A-R, the first residue is an oxoproline and the fifth, a threonine, bears the single carbohydrate chain of the protein molecules. Variations in the glycan chain composition account for the differences in the Mr of PSP S2-5. The PSP S2-5 forms are very soluble in aqueous solutions between the pH values 5.0-9.0, whereas the proteolysated form is scarcely soluble.

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Citations

Jan 1, 1989·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·Z AdrichM Rovery
Mar 22, 2005·Biochimica Et Biophysica Acta·Emmanuelle LaurineJean-Michel Verdier
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·T WatanabeH Kondo
Nov 1, 1991·Digestive Diseases and Sciences·K N Rao, D H Van Thiel
Jan 1, 1995·Journal of Clinical Laboratory Analysis·M KatoT Hayakawa
Jan 1, 1994·Journal of Clinical Laboratory Analysis·N TatemichiY Nakae
Jan 1, 1993·Journal of Clinical Laboratory Analysis·N TatemichiY Nakae
Jun 18, 2005·Molecular & Cellular Proteomics : MCP·Linghua QiuJohn J Kopchick
Jun 29, 1994·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·S Karlin
May 1, 1992·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·L HerickhoffJ Robertson
Feb 11, 2020·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Rolf Graf
Jan 8, 2000·The Journal of Biological Chemistry·V GerbaudJ M Verdier

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