N1 and P300 abnormalities in patients with schizophrenia, epilepsy, and epilepsy with schizophrenialike features

Biological Psychiatry
J M FordA Pfefferbaum

Abstract

The scalp-recorded N1 and P300 components of the event-related brain potential (ERP) are commonly reduced in patients with schizophrenia but not in patients with epilepsy. Epilepsy patients with interictal chronic schizophrenialike features (EPI-SZ) provide a comparison group for determining whether the ERP amplitude abnormalities seen in schizophrenic patients are associated with shared clinical features of EPI-SZ and schizophrenic patients or overlapping pathophysiologies, or are specific to a distinct schizophrenia etiology. Patients with schizophrenia (n = 24) were compared with normal control subjects (n = 32) and patients with epilepsy syndromes on visual and auditory oddball ERP paradigms. Epilepsy patients included those with chronic interictal schizophrenialike features (n = 6) and those without (n = 16). Auditory P300 amplitude was reduced in both schizophrenic and EPI-SZ patients, whose positive or negative symptoms did not differ. In contrast, N1 amplitude was reduced only in schizophrenic patients. Delays in both N1 and P300 were associated with epilepsy patients and EPI-SZ but not schizophrenic patients. The schizophrenialike symptoms in epilepsy probably represent a phenocopy of schizophrenia with common clinical...Continue Reading

References

Feb 1, 1979·Electroencephalography and Clinical Neurophysiology·R Coppola
Aug 11, 1992·Archives of General Psychiatry·J B WilliamsB Rounsaville
Sep 1, 1990·Electroencephalography and Clinical Neurophysiology·M E SmithP Chauvel
Jan 1, 1991·Schizophrenia Bulletin·K T MueserR L Morrison
Feb 1, 1991·Archives of Neurology·C A NelsonF Torres
Dec 1, 1988·Brain : a Journal of Neurology·R Johnson
Aug 1, 1985·The American Journal of Psychiatry·P J McKennaK Parrish
Jan 1, 1985·Schizophrenia Bulletin·M F Pogue-Geile, M Harrow
Dec 1, 1982·The British Journal of Psychiatry : the Journal of Mental Science·B Pfohl, G Winokur
Mar 1, 1994·Electroencephalography and Clinical Neurophysiology·J M FordA Pfefferbaum
Feb 1, 1996·Electroencephalography and Clinical Neurophysiology·M WagnerR R Engel
Feb 1, 1996·Alcoholism, Clinical and Experimental Research·G RamachandranA Litke
Jan 23, 1999·Biological Psychiatry·D F SalisburyR W McCarley
May 1, 1999·Seizure : the Journal of the British Epilepsy Association·A SoysalB Arpaci
Jan 1, 1963·The British Journal of Psychiatry : the Journal of Mental Science·E SLATERE GLITHERO

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Citations

Jan 23, 2004·Brain Research. Cognitive Brain Research·Brett A ClementzJohanna Kissler
Jul 5, 2005·Brain Research. Cognitive Brain Research·Casey S GilmorePeter F Buckley
Jun 18, 2002·Neuroscience Research·Kiyoto KasaiMasato Fukuda
Apr 15, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Charalabos PapageorgiouGeorge N Christodoulou
Oct 19, 2002·Biological Psychology·Bernice PorjeszTheodore Reich
Nov 6, 2002·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·K J BrownE Gordon
Oct 5, 2011·Proceedings of the National Academy of Sciences of the United States of America·Gregory C CarlsonSteven J Siegel
Sep 12, 2009·Schizophrenia Bulletin·R Alison AdcockSophia Vinogradov
Oct 17, 2009·Schizophrenia Bulletin·Daniel C Javitt
Apr 13, 2004·Neuroreport·Carrie R BrumbackMonica Fabiani
Mar 31, 2009·Annual Review of Clinical Psychology·Daniel C Javitt
Apr 2, 2013·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Mirjam J van TrichtDorien H Nieman
May 4, 2011·Biological Psychology·Mirjam J van TrichtLieuwe de Haan
Nov 8, 2008·Psychiatry Research·Bruce I TuretskyRaquel E Gur
Aug 30, 2008·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Julieta Ramos-LoyoCanan Basar-Eroglu
Apr 3, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Timm RosburgNash N Boutros
Jan 20, 2007·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Cherrie A GalletlyC Richard Clark
Apr 1, 2011·Psychophysiology·Pamela BaessErich Schröger
Aug 19, 2009·Psychophysiology·Patrick J C May, Hannu Tiitinen
Oct 7, 2004·Psychiatry Research·Gabriele SachsHeinz Katschnig
Feb 28, 2015·Annals of the New York Academy of Sciences·Daniel C Javitt
May 26, 2009·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Casey S GilmorePatrick Berg
Sep 2, 2014·Frontiers in Psychiatry·Anders Lillevik ThorsenElse-Marie Løberg
May 13, 2008·Schizophrenia Research·Ales UrbanJan Libiger
Jan 16, 2008·International Journal of Audiology·Alexandra Muller-GassKenneth Campbell
May 19, 2017·Clinical EEG and Neuroscience·Kathryn RiegerThomas Koenig
Jul 13, 2005·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Susan M WoodChaiyapoj Netsiri
Jun 19, 2009·Clinical EEG and Neuroscience·Silvana GalderisiNash Boutros
Jul 1, 2016·Scientific Reports·Weifeng LiHanjun Liu
May 29, 2004·American Journal of Physical Medicine & Rehabilitation·Henry L LewElaine S Date
Oct 3, 2003·Clinical EEG (electroencephalography)·Eric R Braverman, Kenneth Blum
Mar 29, 2018·Scientia pharmaceutica·Kandhasamy SowndhararajanSongmun Kim
Dec 14, 2018·Frontiers in Neuroscience·Katharina KunzelmannThomas Dierks

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