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N368-Tau fragments generated by legumain are detected only in trace amount in the insoluble Tau aggregates isolated from AD brain

Acta Neuropathologica Communications

Nov 13, 2019

Kerstin SchlegelLaura Gasparini

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Abstract

Intraneuronal insoluble inclusions made of Tau protein are neuropathological hallmarks of Alzheimer Disease (AD). Cleavage of Tau by legumain (LGMN) has been proposed to be crucial for aggregation of Tau into fibrils. However, it remains unclear if LGMN-cleaved Tau fragments accumulate ...read more

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Alzheimer's Disease
Brain
Hippocampus (Brain)
Laboratory mice
Mass Spectrometry
Viruses, Unclassified
Thioflavin T
Tau Proteins
Asparaginylendopeptidase
Site
1
1
7
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N368-Tau fragments generated by legumain are detected only in trace amount in the insoluble Tau aggregates isolated from AD brain

Acta Neuropathologica Communications

Nov 13, 2019

Kerstin SchlegelLaura Gasparini

PMID: 31722749

DOI: 10.1186/s40478-019-0831-2

Abstract

Intraneuronal insoluble inclusions made of Tau protein are neuropathological hallmarks of Alzheimer Disease (AD). Cleavage of Tau by legumain (LGMN) has been proposed to be crucial for aggregation of Tau into fibrils. However, it remains unclear if LGMN-cleaved Tau fragments accumulate ...read more

Mentioned in this Paper

Alzheimer's Disease
Brain
Hippocampus (Brain)
Laboratory mice
Mass Spectrometry
1
1
7

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