N6-cyclopentyladenosine impairs passive avoidance retention by selective action at A1 receptors

Brain Research Bulletin
H J Normile, R A Barraco

Abstract

The effects of N6-cyclopentyladenosine (CPA), a highly selective agonist for adenosine A1 receptors, on retention of one-trial inhibitory avoidance behavior were examined in mice. Water-deprived animals were trained to avoid drinking by pairing foot-shock with licks from a water spout. Retention was measured as the suppression of drinking (latency to drink) 48 h following training. Administration of CPA (0.15-2.25 mumol/kg) 30 min prior to training produced a dose-dependent impairment in memory of the original avoidance task. The CPA-elicited deficits in retention performance were blocked by pretreatment with 8-cyclopentyl-1,3-dipropylxanthine (DPCPX), a selective A1 receptor antagonist; DPCPX (15 mumol/kg) administration alone had no effect on retention performance. These findings suggest that selective activation of a presumably central population of A1 receptors may impair retention performance and influence information processing.

References

Oct 30, 1990·Neuroscience Letters·A AraiG Lynch
Jul 2, 1990·Brain Research·Y TanakaS Hayashi
Oct 16, 1990·Neuroscience Letters·J L Stringer, E W Lothman
Mar 21, 1989·European Journal of Pharmacology·K Herrick-DavisS J Ward
Jan 1, 1989·Neurochemistry International·M Williams

❮ Previous
Next ❯

Citations

Feb 1, 1996·Psychopharmacology·N HooperT W Stone
May 2, 1994·European Journal of Pharmacology·M R Zarrindast, B Shafaghi
Mar 1, 1996·Trends in Pharmacological Sciences·K A JacobsonB B Fredholm
Nov 1, 1995·Progress in Neuro-psychopharmacology & Biological Psychiatry·L MolinengoP Ghi
Jan 1, 1993·Brain Research Bulletin·R A BarracoH J Normile
Apr 12, 2005·Neurobiology of Learning and Memory·Grace Schenatto PereiraIván Izquierdo
Nov 17, 2001·European Journal of Pharmacology·H HomayounM R Zarrindast
Mar 14, 2002·European Journal of Pharmacology·Grace S PereiraCarla D Bonan
Jun 11, 1997·European Journal of Pharmacology·S N MandhaneA K Ghosh
Sep 1, 1994·Behavioral and Neural Biology·H J NormileR A Barraco
Dec 28, 1999·Brain Research. Brain Research Reviews·J L Moreau, G Huber
Jun 28, 2001·Brain Research Bulletin·M S GevaerdC Da Cunha
Feb 13, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Bruno M FontinhaAgnès Gruart
Apr 28, 2001·British Journal of Pharmacology·K PlaschkeH J Bardenheuer
Aug 16, 2000·Neuroreport·R RoeslerD O Souza
Sep 13, 2011·Progress in Neurobiology·Geoffrey BurnstockPeter Illes
Jun 12, 2013·Neuroscience Letters·Craig VollertJason L Eriksen
Feb 15, 2011·Neuropharmacology·Detlev BoisonBenjamin K Yee
Sep 28, 2016·Proceedings of the National Academy of Sciences of the United States of America·Frank J A DennissenEva-Maria Mandelkow
Dec 21, 2006·Journal of Radiation Research·Bing HouCheng-Gang Zhang
Nov 24, 2020·Chemické Zvesti·Helena D Janse van RensburgGisella Terre'Blanche
Mar 30, 2021·Neuroscience and Biobehavioral Reviews·Andrew B LehrTristan M Stöber
Dec 9, 2021·Chemical Biology & Drug Design·Chrisna MattheeLesetja J Legoabe

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.