PMID: 7542697May 1, 1995Paper

Na(+)-activated nonselective cation channels in primary olfactory neurons

Journal of Neurophysiology
A B Zhainazarov, B W Ache

Abstract

1. Excised inside-out patch recordings were used to describe a novel cation channel from cultured lobster olfactory receptor neurons that is activated by [Na+]i. 2. The channel is reversibly activated by intracellular Na+ as low as 5 mM. The half-effect concentration of intracellular Na+ is approximately 60 mM at -60 mV. The dependence of the channel open probability on [Na+]i is sigmoidal with a Hill coefficient of 3.1, indicating that more than one Na+ must bind to activate the channel. 3. The channel is equally permeable to Na+, K+, and Li+. In symmetrical 210 mM Na+, the open channel current-voltage relationship shows slight inward rectification at positive potentials. The slope conductance of the channel is 107 pS between -90 and 0 mV. 4. Although the channel is not activated by voltage in the absence of intracellular Na+, the gating of the channel is dependent on voltage as well as [Na+]i and [Na+]o. 5. Both intracellular Ca2+ and Mg2+ reversibly affect channel activity in a concentration-dependent manner starting at 1 microM. Ca2+ decreases both the open probability and the single channel amplitude, whereas Mg2+ decreases the open probability but has no effect on the single channel amplitude. Ba2+ (5 mM), but not 20 mM C...Continue Reading

Citations

May 2, 1998·Journal of Neurophysiology·A B ZhainazarovB W Ache
Jan 19, 2013·Chemical Senses·Katharina RölleckeGünter Gisselmann
Jun 2, 2001·Journal of Neurophysiology·A B ZhainazarovB W Ache
Apr 30, 1998·Physiological Reviews·D Schild, D Restrepo
Dec 24, 1998·Journal of Neurophysiology·A B Zhainazarov, B W Ache

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