Na(+) /Ca(2+) exchanger-heterozygote knockout mice display increased relaxation in gastric fundus and accelerated gastric transit in vivo

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
Y T AzumaTadayoshi Takeuchi

Abstract

For the contraction and relaxation of gastric smooth muscles to occur, the intracellular Ca(2+) concentration must be increased and decreased, respectively. The Na(+) /Ca(2+) exchanger (NCX) is a plasma membrane transporter that is involved in regulating intracellular Ca(2+) concentrations. To determine the role of NCX in gastrointestinal tissues, we examined electric field stimulation (EFS)-induced relaxations in the circular muscles of the gastric fundus in NCX1 and NCX2 heterozygote knockout mice (HET). The myenteric plexus layers and the longitudinal and circular muscle layers in the gastric fundus of wild-type mice (WT) were strongly immunoreactive to NCX1 and NCX2. EFS induced a transient relaxation that was apparent during the stimulus and a sustained relaxation that persisted after the end of the stimulus. The amplitudes of EFS-induced transient relaxation and sustained relaxation were greater in NCX1 HET and NCX2 HET than in WT. When an inhibitor of nitric oxide synthase was added following the EFS, neither NCX1 HET nor NCX2 HET exhibited transient relaxation, similar to WT. Furthermore, when a PACAP antagonist was added following the EFS, sustained relaxation in NCX1 HET and NCX2 HET was not observed, similar to WT. N...Continue Reading

References

May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·I KomuroS Izumo
Oct 4, 1996·The Journal of Biological Chemistry·D A NicollK D Philipson
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·A J BurnsS M Ward
Nov 11, 1998·General Pharmacology·D Currò, P Preziosi
Feb 17, 2001·Regulatory Peptides·M C Baccari, F Calamai
Nov 25, 2003·Advances in Physiology Education·Susan V Brooks
Nov 25, 2003·Advances in Physiology Education·R Clinton Webb
Nov 22, 2005·Trends in Cardiovascular Medicine·Takahiro IwamotoTakeshi Katsuragi
Feb 21, 2006·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T TakeuchiF Hata
Sep 30, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Tadayoshi TakeuchiYasu-Taka Azuma
Jan 22, 2008·Journal of Cellular Physiology·Yasu-Taka AzumaTadayoshi Takeuchi
Jul 8, 2008·European Journal of Pharmacology·Kiyomi HagiTadayoshi Takeuchi
Oct 17, 2009·Inflammatory Bowel Diseases·Yasu-Taka AzumaTadayoshi Takeuchi
Jan 21, 2010·Physiological Reviews·Susan Wray, Theodor Burdyga
Jul 24, 2010·International Immunopharmacology·Yasu-Taka AzumaTadayoshi Takeuchi
Dec 15, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hiroshi MiharaMakoto Tominaga
Apr 28, 2011·Journal of Pharmacological Sciences·Toru OdaAkinori Akaike
Sep 14, 2012·Journal of Pharmacological Sciences·Tomomi YamakawaJunko Kimura
Oct 18, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Y T AzumaT Takeuchi
Jul 30, 2014·Journal of Pharmacological Sciences·Daisuke MoriMasatoshi Hori
Dec 17, 2014·Biochemical and Biophysical Research Communications·Yusuke GotohTakahiro Iwamoto

❮ Previous
Next ❯

Citations

Jul 15, 2016·Naunyn-Schmiedeberg's Archives of Pharmacology·Kazuhiro NishiyamaTadayoshi Takeuchi
Dec 9, 2016·The Journal of Veterinary Medical Science·Kazuhiro NishiyamaTadayoshi Takeuchi
Oct 15, 2018·Journal of Cellular Physiology·Kazuhiro NishiyamaYasu-Taka Azuma
Feb 2, 2018·Biological & Pharmaceutical Bulletin·Yasuyuki FujimotoYasu-Taka Azuma
Jan 29, 2019·World Journal of Gastroenterology : WJG·Qiu-Shi LiaoRui Xie

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.