PMID: 9542264Jan 1, 1997Paper

Na(+)-H+ exchange activity throughout pregnancy: the proper experimental approach

Annali Dell'Istituto Superiore Di Sanità
E Matteucci, O Giampietro

Abstract

Pregnancy is associated with a 30-50% rise in cardiac output and a close to 50% increase in blood volume. The Na(+)-H+ exchanger is a key mediator of tubular NaCl absorption and a stimulus-response coupling mediator. We measured erythrocyte Na(+)-H+ exchange activity over the course of normal pregnancy in 18 healthy pregnant women (mean age 32 +/- 4 years) at 14, 24 and 33 weeks of gestation and 15 nonpregnant healthy women (mean age 32 +/- 9 years). No pregnancy was complicated by hypertension. Serum urea, creatinine and sodium did not change through gestation, while serum potassium slightly but significantly decreased. Urinary excretion rates of both sodium and potassium remained unchanged. Urea and creatinine clearances were constantly elevated in pregnant vs non-pregnant control women. Erythrocyte Na(+)-H+ exchanger reached the highest activity at about the 14th week of gestation, when cardiac output also peaked. Thereafter, it tended to decrease, yet remaining above the normal values until the 34th week. Conceivably, the observed hyperactivity of the transporter may be a contributing factor to the hemodynamic adjustments attending to normal pregnancy.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Annamaria MaglioneMaria Pia Longo
Nihon Geka Gakkai zasshi
K KinugasaM Okada
© 2022 Meta ULC. All rights reserved