Na+ /H+ exchanger isoform 1-induced osteopontin expression facilitates cardiac hypertrophy through p90 ribosomal S6 kinase

Physiological Genomics
Nabeel AbdulrahmanFatima Mraiche

Abstract

Cardiovascular diseases are the leading cause of death worldwide. One in three cases of heart failure is due to dilated cardiomyopathy. The Na+/H+ exchanger isoform 1 (NHE1), a multifunctional protein and the key pH regulator in the heart, has been demonstrated to be increased in this condition. We have previously demonstrated that elevated NHE1 activity induced cardiac hypertrophy in vivo. Furthermore, the overexpression of active NHE1 elicited modulation of gene expression in cardiomyocytes including an upregulation of myocardial osteopontin (OPN) expression. To determine the role of OPN in inducing NHE1-mediated cardiomyocyte hypertrophy, double transgenic mice expressing active NHE1 and OPN knockout were generated and assessed by echocardiography and the cardiac phenotype. Our studies showed that hearts expressing active NHE1 exhibited cardiac remodeling indicated by increased systolic and diastolic left ventricular internal diameter and increased ventricular volume. Moreover, these hearts demonstrated impaired function with decreased fractional shortening and ejection fraction. Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) mRNA was upregulated, and there was an increase in heart cell cross-sectional ...Continue Reading

References

Jul 14, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S R RittlingD T Denhardt
May 7, 2003·Hypertension·Irene L EnnisHoracio E Cingolani
Jan 9, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Kenichi ImahashiLarry Fliegel
Oct 2, 2007·Journal of the American College of Cardiology·Mariangela SebastianiGiulia d'Amati
Oct 3, 2007·Journal of Cellular Biochemistry·Christian C KazaneckiDavid T Denhardt
Dec 10, 2008·Expert Opinion on Therapeutic Targets·Larry Fliegel
Jan 13, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Tepmanas Bupha-IntrPaul M L Janssen
Mar 26, 2009·Journal of Molecular and Cellular Cardiology·Sabzali JavadovMorris Karmazyn
Apr 17, 2010·Cardiology in Review·Alfonso H WallerMarc Klapholz
Sep 3, 2010·The Journal of Clinical Investigation·Polakit TeekakirikulJonathan G Seidman
Dec 22, 2010·Circulation·Izhak Kehat, Jeffery D Molkentin
Mar 2, 2011·Basic Research in Cardiology·Fatima MraicheLarry Fliegel
Jan 4, 2012·Basic Research in Cardiology·Jakob VoelklFlorian Lang
Apr 27, 2012·Physiological Reviews·Nikolaos G Frangogiannis
Feb 14, 2013·Molecular Pharmacology·Robert S PapayDianne M Perez
Feb 23, 2013·Journal of Molecular and Cellular Cardiology·Morris Karmazyn
Jul 19, 2013·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Jakob VoelklFlorian Lang
Mar 10, 2015·Journal of Applied Physiology·Mariela B NollyPatricio E Morgan
Mar 12, 2015·Molecular and Cellular Biochemistry·Mohamed MlihFatima Mraiche
Sep 1, 2015·Circulation Research·Haipeng SunYibin Wang
Jan 27, 2017·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Mar 23, 2017·Frontiers in Cell and Developmental Biology·Linda T Senbanjo, Meenakshi A Chellaiah

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Citations

Dec 11, 2019·Cells·Iman Abdelaziz MohamedFatima Mraiche
Aug 12, 2020·European Journal of Pharmacology·Sadaf RiazFatima Mraiche

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Methods Mentioned

BETA
genotyping
PCR
protein assay
Transgenic
transfection

Software Mentioned

Scion

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