Sep 1, 1977

Na+-K+-ATPase activity in guinea pig brain synaptosomal fraction in experimental allergic encephalomyelitis

Ukrainskiĭ biokhimicheskiĭ zhurnal
J V BelikH A Berezhnyj


The activity Na+, K+-ATPase of the guinea pig brain synaptosome fraction as well as the effect on this enzyme of the blood serum obtained in guinea pigs in different periods after sensibilization of the animals with the basic encephalitogenic protein were studied in dynamics of experimental allergic encephalomyelitis development. The Na+,K+-ATPase activity in the guinea pig brain synaptosome fraction is more than 50% lower from the seventh day of sensibilization up to development of characteristic symptoms of the disease in animals. The guinea pigs blood serum obtained on the seventh and tenth days of sensibilization has an inhibitory effect of the same order on the studied activity of the normal guinea pig brain synaptosome fraction. At the later stages of the disease development and with the presence of characteristic symptoms of experimental allergic encephalomyelitis in the animals the blood serum has no similar effect.

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Mentioned in this Paper

Neurologic Manifestations
Adenosine Triphosphatases
Experimental Autoimmune Encephalomyelitis
Myelin Basic Protein, Isoform 4
Sodium/Potassium-exchanging ATPase Activity
DNA-dependent ATPase

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