Na+-K+ pump stimulation improves contractility in damaged muscle fibers

Annals of the New York Academy of Sciences
Torben Clausen

Abstract

Skeletal muscles have a high content of Na+-K+-ATPase, an enzyme that is identical to the Na+-K+ pump, a transport system mediating active extrusion of Na+ from the cells and accumulation of K+ in the cells. The major function of the Na+-K+ pumps is to maintain the concentration gradients for Na+ and K+ across the plasma membrane. This generates the resting membrane potential, allowing the propagation of action potentials, excitation-contraction coupling and force development. Muscles exposed to (1) high extracellular K+ or (2) low extracellular Na+ show a considerable loss of force. A similar force decline is elicited by (3) increasing Na+ permeability or (4) decreasing K+ permeability. Under all of these four conditions, stimulation of the Na+-K+ pumps can restore contractility. Following exposure to electroporation or fatiguing stimulation, muscle cell membranes develop leaks to Na+ and K+ and a partially reversible loss of force. The restoration of force is abolished by blocking the Na+-K+ pumps and markedly improved by stimulating the Na+-K+ pumps with beta 2-agonists, calcitonin gene-related peptide, or dbcAMP. These observations indicate that the Na+-K+ pumps are important for the functional compensation of the commonly ...Continue Reading

References

Jul 1, 1992·The American Review of Respiratory Disease·E DeromM Decramer
Jul 1, 1990·Plastic and Reconstructive Surgery·D L BhattR C Lee
Jun 1, 1995·The American Journal of Physiology·R BouclinJ M Renaud
Dec 1, 1993·The Journal of Physiology·T ClausenJ A Flatman
Mar 1, 1993·Journal of Applied Physiology·A N Belcastro
Aug 1, 1997·Pflügers Archiv : European journal of physiology·K OvergaardT Clausen
Oct 23, 1997·The Journal of Physiology·O B Nielsen, T Clausen
Aug 5, 2000·Journal of Applied Physiology·K CollompJ De Ceaurriz
Nov 1, 2002·American Journal of Physical Medicine & Rehabilitation·Priscilla M Clarkson, Monica J Hubal
May 24, 2003·Annals of the New York Academy of Sciences·Torben Clausen
Sep 25, 2003·Physiological Reviews·Torben Clausen
Dec 14, 2004·Journal of Applied Physiology·Jatin G BurnistonDavid F Goldspink
Oct 8, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ulla Ramer MikkelsenTorben Clausen

❮ Previous
Next ❯

Citations

Mar 24, 2010·European Radiology·Gregory ChangRavinder R Regatte
Sep 4, 2009·Medicine and Science in Sports and Exercise·Nosratollah HedayatpourDario Farina
Jul 15, 2015·Academic Radiology·Matthias HammonJens Titze
Jan 17, 2015·Fatigue : Biomedicine, Health & Behavior·Stuart GoodallMarkus Amann
Jan 10, 2018·Muscle & Nerve·James H F LeeKarl Ng
Jul 23, 2019·Muscle & Nerve·James H F LeeKarl Ng
Jul 8, 2020·Cells·Preethi Poovathumkadavil, Krzysztof Jagla

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.