Na+ transport in cystic fibrosis respiratory epithelia. Abnormal basal rate and response to adenylate cyclase activation

The Journal of Clinical Investigation
R C BoucherJ T Gatzy

Abstract

The transepithelial potential difference (PD) of cystic fibrosis (CF) airway epithelium is abnormally raised and the Cl- permeability is low. We studied the contribution of active Na+ absorption to the PD and attempted to increase the Cl- permeability of CF epithelia. Nasal epithelia from CF and control subjects were mounted in Ussing chambers and were short-circuited. The basal rate of Na+ absorption was raised in CF polyps compared with control tissues. Whereas beta agonists induced Cl- secretion in normal and atopic epithelia, beta agonists further increased the rate of Na+ absorption in CF epithelia without inducing Cl- secretion. This unusual effect is not due to an abnormal CF beta receptor because similar effects were induced by forskolin, and because cAMP production was similar in normal and CF epithelia. We conclude that CF airway epithelia absorb Na+ at an accelerated rate. The abnormal response to beta agonists may reflect a primary abnormality in a cAMP-modulated path, or a normal cAMP-modulated process in a Cl- impermeable epithelial cell.

References

Nov 24, 1982·Biochimica Et Biophysica Acta·C M LiedtkeS A Rudolph
Jun 26, 1980·The New England Journal of Medicine·P B DavisM Kaliner
Jul 1, 1981·The Journal of Clinical Investigation·S P GalantC Wood
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·K B SeamonJ W Daly
Jan 1, 1981·Annals of the New York Academy of Sciences·R A FrizzellP L Smith
Jun 1, 1983·The Journal of Clinical Investigation·P B DavisC F Doershuk
Jan 1, 1982·The Journal of Membrane Biology·P L SmithR A Frizzell
Jan 1, 1982·The Journal of Membrane Biology·M J WelshR A Frizzell
Jun 1, 1984·The Journal of Clinical Investigation·K Sato, F Sato
Feb 3, 1983·Nature·P M Quinton
May 1, 1983·The Journal of Clinical Investigation·M KnowlesR Boucher
Dec 17, 1981·The New England Journal of Medicine·M KnowlesR Boucher

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Citations

Jul 1, 1996·The Journal of Experimental Zoology·J W HanrahanJ R Riordan
Dec 1, 1996·Pediatric Pulmonology·E Kerem, B Kerem
Dec 22, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Marcus Mall, Karl Kunzelmann
Nov 1, 1991·Pflügers Archiv : European journal of physiology·D CremaschiV Aliverti
Nov 1, 1995·Pflügers Archiv : European journal of physiology·K KunzelmannR Greger
Aug 17, 1989·Klinische Wochenschrift·A SchusterD Reinhardt
Jan 1, 1988·Journal of Inherited Metabolic Disease·M A McPherson
Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Mary Jayne Kennedy
Feb 8, 2006·The Journal of Membrane Biology·M M Reddy, P M Quinton
Feb 24, 2007·European Journal of Applied Physiology·Alexandra HebestreitHelge Hebestreit
Dec 24, 2005·Pflügers Archiv : European journal of physiology·Asser Nyander PoulsenOle Frederiksen
Apr 12, 2005·Pflügers Archiv : European journal of physiology·Asser Nyander PoulsenOle Frederiksen
Jul 30, 2008·Pflügers Archiv : European journal of physiology·I A GreenwoodD L Baines
Apr 20, 2010·Pflügers Archiv : European journal of physiology·Erol A GaillardRobert Tarran
Jan 11, 2012·Protein & Cell·Huibi CaoJim Hu
Mar 2, 1994·Biochemical Pharmacology·D P FallerM P Ryan
Dec 1, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·M A McPhersonM C Goodchild
Oct 31, 1994·Clinica Chimica Acta; International Journal of Clinical Chemistry·M M UlaneV S Hubbard
Jan 1, 1991·Life Sciences·T M Dwyer, J M Farley
Apr 24, 1993·Lancet·C Koch, N Høiby
Aug 1, 1996·Trends in Pharmacological Sciences·S Demolombe, D Escande
Jan 1, 1991·Comparative Biochemistry and Physiology. A, Comparative Physiology·D CremaschiV Aliverti
Nov 25, 1993·Biochimica Et Biophysica Acta·S DhoJ K Foskett
Mar 1, 1995·Biologicals : Journal of the International Association of Biological Standardization·C Coutelle
Jun 7, 2005·Pharmacology & Therapeutics·Chunying Li, Anjaparavanda P Naren
Jul 23, 1998·The American Journal of Medicine·E M SchwiebertC M Fuller
Feb 23, 2002·European Journal of Pharmacology·Judith C W MakPeter J Barnes
Aug 1, 1989·The Journal of Pediatrics·B StrandvikE Kusoffsky
Apr 1, 1995·Trends in Pharmacological Sciences·A Knox, D Peckham
Apr 1, 1995·Trends in Pharmacological Sciences·M R BoarderG F Wilkinson
Nov 30, 2002·Advanced Drug Delivery Reviews·R C Boucher
Nov 20, 1997·Comparative Biochemistry and Physiology. Part A, Physiology·B R Grubb
Aug 1, 1997·Current Opinion in Cell Biology·S Devidas, W B Guggino
Dec 16, 1997·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·B C Hilman
Sep 26, 2002·Paediatric Respiratory Reviews·Edith PuchelleMichel Abély
Jun 17, 2011·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Zhe ZhouMarcus A Mall
May 1, 1993·Nature Genetics·R RatcliffW H Colledge
May 1, 1997·Nature Medicine·J J Wine
May 12, 2000·British Journal of Pharmacology·S K InglisS M Wilson
May 18, 2010·Integrative Biology : Quantitative Biosciences From Nano to Macro·Chunying Li, Anjaparavanda P Naren
Nov 15, 2002·Journal of Anatomy·J H Widdicombe

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