PMID: 6127380Sep 1, 1982Paper

Nabumetone (BRL 14777, 4-[6-methoxy-2-naphthyl]-butan-2-one): a new anti-inflammatory agent

The Journal of Pharmacy and Pharmacology
E A BoyleM J Thomson

Abstract

Nabumetone is a compound of novel structure which displays acute anti-inflammatory activity in the carrageenan-induced oedema model in rats and the ultraviolet-induced erythema model in guinea-pigs. Its activity in these tests is greater than that of aspirin but less than that of naproxen and indomethacin. In the cotton pellet-induced granuloma model in the rat, the compound is active and produces no signs of toxicity at doses much greater than the lowest effective dose, unlike aspirin, naproxen or indomethacin. Nabumetone is also active in the adjuvant-induced arthritis test in rats. In contrast to aspirin, indomethacin and naproxen, the compound is well tolerated by the stomach of fasted rats at doses in excess of those with anti-inflammatory activity. These findings could be linked to the relatively poor ability of nabumetone to inhibit the synthesis of prostaglandins in vitro and to its non-acidic structure. The compound has greater mild analgesic activity than paracetamol, is equi-active with phenylbutazone, but less active than aspirin, naproxen and indomethacin. Nabumetone also has antipyretic activity in the rabbit. No interactions with the hypothalamic-pituitary-adrenal axis have been found.

References

Dec 1, 1976·The Journal of Pharmacy and Pharmacology·E BoyleM Thomson
Mar 1, 1979·Biochemical Pharmacology·P C FreemanD K Watkins
Jan 1, 1976·Drugs·F D Hart
Aug 1, 1974·Agents and Actions·M E RosenthaleM I Gluckman
Dec 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·P WarrickC M Gruber
Jan 1, 1974·Current Medical Research and Opinion·M F Cuthbert
Dec 1, 1962·Proceedings of the Society for Experimental Biology and Medicine·C A WINTERG W NUSS

❮ Previous
Next ❯

Citations

Jun 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·C J GrossmanP J Birch
May 30, 2001·Journal of Ethnopharmacology·T Geetha, P Varalakshmi
May 1, 1992·The Journal of Pharmacy and Pharmacology·G B SinghS K Banerjee
Oct 30, 1987·The American Journal of Medicine·P N Jenner
Oct 30, 1987·The American Journal of Medicine·R A TurnerF N Mitchell
Oct 30, 1987·The American Journal of Medicine·R D Brobyn
Oct 30, 1987·The American Journal of Medicine·F R ManganD Jackson
Sep 1, 1995·Clinical Pharmacology and Therapeutics·F CipolloneP Patrignani
May 31, 2002·Journal of Human Hypertension·T ReitblatJ R Viskoper
Jun 6, 2020·Natural Product Research·Sakshi BajajNeeraj Fuloria
Mar 15, 2003·The Journal of Pharmacy and Pharmacology·Yoshiro IshiwataToshikazu Yoshikawa
Apr 1, 1984·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R E HaddockA R Thawley
May 1, 1984·The Journal of Pharmacy and Pharmacology·A P GreenE A Boyle
Jun 1, 1983·The Journal of Pharmacy and Pharmacology·R E HaddockI S Pardon
Oct 27, 2018·European Journal of Medicinal Chemistry·Subhajit MakarSushil K Singh
Apr 1, 1994·Seminars in Arthritis and Rheumatism·S M Helfgott
Jun 8, 2021·Angewandte Chemie·Anna V BayKarl A Scheidt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.