NAc Shell Arc/Arg3.1 Protein Mediates Reconsolidation of Morphine CPP by Increased GluR1 Cell Surface Expression: Activation of ERK-Coupled CREB is Required

The International Journal of Neuropsychopharmacology
Xiufang LvJi-Sheng Han

Abstract

Relapse into drug abuse evoked by reexposure to the drug-associated context has been a primary problem in the treatment of drug addiction. Disrupting the reconsolidation of drug-related context memory would therefore limit the relapse susceptibility. Morphine conditioned place preference (CPP) was used to assess activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) and correlative molecule expression in the Nucleus accumbens (NAc) shell during the reconsolidation of morphine CPP. U0126 and Arc/Arg3.1 antisense oligodeoxynucleotide were adapted to evaluate the role and the underlying mechanism of Arc/Arg3.1 during the reconsolidation. The retrieval of morphine CPP in rats specifically increased the Arc/Arg3.1 protein level in the NAc shell, accompanied simultaneously by increases in the phosphorylation of extracellular signal-regulated kinase1/2 (pERK1/2), the phosphorylation of Cyclic Adenosine monophosphate (cAMP) response element-binding (pCREB), and the up-regulation of the membrane α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors GluR1 subunit level. Intra-NAc shell infusion U0126, an inhibitor of the Mitogen-activated protein kinase kinase (MEK), prevented the retrieval-induced up-regulation of ...Continue Reading

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Citations

Jan 24, 2017·The European Journal of Neuroscience·Jiangyong OuyangKenneth D Carr
Jul 5, 2019·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Qiuting WangJinhao Sun
Aug 18, 2018·Learning & Memory·Marc T J Exton-McGuinness, Amy L Milton
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Apr 7, 2021·Cellular and Molecular Life Sciences : CMLS·Ernest T ChiveroGuoku Hu
May 25, 2021·Computational and Structural Biotechnology Journal·Leisheng ShiMei Zhao

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