PMID: 9431856Feb 12, 1998Paper

NaCl sensitivity of essential hypertensive patients is related to insulin resistance

Journal of Hypertension
F GallettiM Mancini

Abstract

To evaluate insulin sensitivity of essential hypertensive patients with different salt sensitivities of blood pressure in the absence of confounding factors such as obesity, glucose intolerance and the inclusion both of normotensive and of hypertensive subjects that have affected most previous studies. Ninety-nine patients with untreated mild or moderate essential hypertension, World Health Organization class I-II, participated in the study. Salt sensitivity was estimated using the Weinberger protocol with minor modifications and the patients were classified into tertiles of salt sensitivity. Patients with high NaCl sensitivities were slightly older and had somewhat higher blood pressures than did subjects with low salt sensitivities. Plasma renin activity significantly decreased with increasing salt sensitivity. There were no differences among the three groups in terms of body mass index, fasting blood glucose and insulin plasma levels. There were no differences among the groups in the integrated glucose and insulin response to a standard oral-glucose tolerance test However, there was a significant difference in insulin sensitivity between two subgroups of the upper and lower tertile of salt sensitivity, the salt-sensitive hyp...Continue Reading

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Citations

Sep 17, 2013·Reviews in Endocrine & Metabolic Disorders·P Anil KumarG Bhanuprakash Reddy
Apr 29, 2010·Current Hypertension Reports·Jing Chen
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