NaCl-triggered self-assembly of hydrophilic poloxamine block copolymers

International Journal of Pharmaceutics
Anita BahadurPratap Bahadur

Abstract

Tetronic 1307 (T1307) is a hydrophilic poloxamine (HLB>24) with a high molecular mass owing to its long PEO and PPO blocks. In spite of good biocompatibility, its use as a component of drug delivery systems is limited by its high critical micelle concentration (CMC) and temperature (CMT). The aim of this work was to elucidate whether the addition of NaCl or the combination of salts and temperature may bring T1307 micellization and gelling features into more practically useful values. Increasing NaCl concentration in the 0.154 M (isotonic) to 2M (hypertonic) range made the copolymer more hydrophobic and more prone to self-assemble into unimodal micelles, as observed by means of π-A isotherms, (1)H NMR, dynamic light scattering (DLS), small-angle neutron scattering (SANS), and pyrene fluorescence. The decrease in CMC and CMT observed for T1307 in 0.5 M NaCl medium (tolerable hypertonic solution), compared to water, notably favored the solubility of hydrophobic drugs such as curcumin and quercetin. Moreover, phase diagram, intrinsic viscosity and sol-to-gel transition were markedly affected by NaCl concentration. Overall, the strong dependence of T1307 self-assembly features on NaCl opens interesting possibilities for tuning the p...Continue Reading

References

Feb 1, 2002·Current Eye Research·S TongeB Tighe
Sep 4, 2004·Biophysical Journal·Canay Ege, Ka Yee C Lee
Apr 20, 2005·Journal of Colloid and Interface Science·Lin-Chau ChangChurn-Shiouh Gau
Mar 15, 2006·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Lakshman N SubbaramanLyndon Jones
Jun 9, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Chengshan WangRoger M Leblanc
Jul 28, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Jun-he MaHui-zhou Liu
Sep 18, 2007·International Journal of Pharmaceutics·David AttwoodNágila M P S Ricardo
Jan 2, 2008·The Journal of Physical Chemistry. B·A G DenkovaM-O Coppens
Aug 30, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Amit K SharmaAlexander V Kabanov
Sep 13, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Jaime Gonzalez-LopezAngel Concheiro
Oct 22, 2008·Journal of Colloid and Interface Science·Gemma E NewbyNicholas J Terrill
Dec 29, 2009·Frontiers in Bioscience (Elite Edition)·Carmen Alvarez-LorenzoAngel Concheiro
Jan 27, 2010·The British Journal of Nutrition·Jenny EpsteinThomas T Macdonald
Feb 24, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Jhony OrbulescuRoger M Leblanc
Jul 6, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Geneviève GaucherJean-Christophe Leroux
Nov 20, 2010·Journal of Colloid and Interface Science·Christopher C PerryDanilo S Boskovic
Dec 7, 2010·Nanomedicine·Carmen Alvarez-LorenzoAlejandro Sosnik
Jul 19, 2012·Angewandte Chemie·Felix H SchacherIan Manners
Mar 28, 2013·Journal of Drug Delivery·Stefano Salmaso, Paolo Caliceti
Apr 23, 2014·Journal of Biomedical Nanotechnology·M Rodríguez-EvoraC Evora
Jul 12, 2014·Journal of Drug Targeting·Masamichi NakayamaTeruo Okano
Sep 18, 2014·Expert Opinion on Drug Delivery·Susana Mn SimõesCarmen Alvarez-Lorenzo
Oct 13, 2014·Current Opinion in Pharmacology·Léa MessagerGiuseppe Battaglia
Nov 27, 2014·ACS Applied Materials & Interfaces·Chun-Yang SunXian-Zhu Yang
Feb 2, 2015·The Journal of Chemical Physics·Tomer MarkovichRudi Podgornik
Feb 24, 2015·Journal of Surfactants and Detergents·Katarzyna StaszakKatarzyna Michocka
May 6, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Gustavo González-GaitanoCécile A Dreiss
Jun 2, 2015·International Journal of Pharmaceutics·Wei Wang
Jun 27, 2015·Colloids and Surfaces. B, Biointerfaces·Isabel Sandez-MachoCarmen Alvarez-Lorenzo

❮ Previous
Next ❯

Citations

Jul 8, 2016·The Journal of Physical Chemistry. B·P ParekhP Bahadur
Jan 30, 2019·Pharmaceutics·Sonia Cabana-MontenegroCarmen Alvarez-Lorenzo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Colloids and Surfaces. B, Biointerfaces
Andreza RibeiroAngel Concheiro
Langmuir : the ACS Journal of Surfaces and Colloids
Gustavo González-GaitanoCécile A Dreiss
Journal of Controlled Release : Official Journal of the Controlled Release Society
Scott R Croy, Glen S Kwon
© 2021 Meta ULC. All rights reserved