NAD+ : A big player in cardiac and skeletal muscle remodeling and aging

Journal of Cellular Physiology
Pankaj Chaturvedi, Suresh C Tyagi

Abstract

In the past decade, NAD+ has gained importance for its beneficial effects as antioxidant and anti-aging molecule. A paper in science by Zhang et al. () has described that NAD+ when replenished, ameliorates muscle dystrophy in mice by improving mitochondrial function. NAD+ was also demonstrated by the authors to improve the life span of mice. Cox et al. () demonstrated the cardiac effects of NAD+ which mitigated chronic heart failure via mitochondrial redox state mechanism. Cox et al. () also demonstrated that NAD+ is provided in the drinking water, it improves cardiac relaxation in volume overload model of heart failure. Although NAD+ has a profound anti-aging and anti-oxidant effects, its effect on humans and use as a dietary supplement needs more exploration.

References

Mar 15, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Michael J CoxSuresh C Tyagi
Sep 9, 2006·Microbiology and Molecular Biology Reviews : MMBR·Paul O HassaMichael O Hottiger

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Citations

Aug 11, 2017·International Journal of Molecular Sciences·Weili Xu, Anis Larbi
Mar 16, 2019·Beilstein Journal of Organic Chemistry·Mikhail V Makarov, Marie E Migaud
Mar 31, 2021·ACS Chemical Biology·Mikhail V MakarovMarie E Migaud

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