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NAD-binding mode and the significance of intersubunit contact revealed by the crystal structure of Mycobacterium tuberculosis NAD kinase-NAD complex

Biochemical and Biophysical Research Communications

Feb 11, 2005

Shigetarou MoriKousaku Murata

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Abstract

NAD kinase is a key enzyme in NADP biosynthesis. We solved the crystal structure of polyphosphate/ATP-NAD kinase from Mycobacterium tuberculosis (Ppnk) complexed with NAD (Ppnk-NAD) at 2.6A resolution using apo-Ppnk structure solved in this work, and revealed the details of the structur...read more

Mentioned in this Paper

DNA Sequence
Homologous Gene
NADP
Carboxy-Terminal Amino Acid
Protein Structure, Quaternary
Adenosine
NADH
Mutation Abnormality
Electron Density
DACT1 gene
Paper Details
References
    • References25
    • Citations16
    • References25
    • Citations16
  • NAD-binding mode and the significance of intersubunit contact revealed by the crystal structure of Mycobacterium tuberculosis NAD kinase-NAD complex

    Biochemical and Biophysical Research Communications

    Feb 11, 2005

    Shigetarou MoriKousaku Murata

    PMID: 15629142

    DOI: 10.1016/j.bbrc.2004.11.163

    Abstract

    NAD kinase is a key enzyme in NADP biosynthesis. We solved the crystal structure of polyphosphate/ATP-NAD kinase from Mycobacterium tuberculosis (Ppnk) complexed with NAD (Ppnk-NAD) at 2.6A resolution using apo-Ppnk structure solved in this work, and revealed the details of the structur...read more

    Mentioned in this Paper

    DNA Sequence
    Homologous Gene
    NADP
    Carboxy-Terminal Amino Acid
    Protein Structure, Quaternary

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    Paper Details
    References
    • References25
    • Citations16
    • References25
    • Citations16
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