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NAD-binding mode and the significance of intersubunit contact revealed by the crystal structure of Mycobacterium tuberculosis NAD kinase-NAD complex

Biochemical and Biophysical Research Communications

Jan 5, 2005

Shigetarou MoriKousaku Murata

Abstract

NAD kinase is a key enzyme in NADP biosynthesis. We solved the crystal structure of polyphosphate/ATP-NAD kinase from Mycobacterium tuberculosis (Ppnk) complexed with NAD (Ppnk-NAD) at 2.6A resolution using apo-Ppnk structure solved in this work, and revealed the details of the structur...read more

Mentioned in this Paper

Nicotinamide Assay
Glycerin
Carboxy-Terminal Amino Acid
Adenosine
Tuberculosis
NAD+ kinase
Electron Density
Mutagenesis, Site-Directed
Protein Structure, Quaternary
Crystallography, X-Ray
Paper Details
References
  • References25
  • Citations18
123
  • References25
  • Citations18
12

NAD-binding mode and the significance of intersubunit contact revealed by the crystal structure of Mycobacterium tuberculosis NAD kinase-NAD complex

Biochemical and Biophysical Research Communications

Jan 5, 2005

Shigetarou MoriKousaku Murata

PMID: 15629142

DOI: 10.1016/j.bbrc.2004.11.163

Abstract

NAD kinase is a key enzyme in NADP biosynthesis. We solved the crystal structure of polyphosphate/ATP-NAD kinase from Mycobacterium tuberculosis (Ppnk) complexed with NAD (Ppnk-NAD) at 2.6A resolution using apo-Ppnk structure solved in this work, and revealed the details of the structur...read more

Mentioned in this Paper

Nicotinamide Assay
Glycerin
Carboxy-Terminal Amino Acid
Adenosine
Tuberculosis
NAD+ kinase
Electron Density
Mutagenesis, Site-Directed
Protein Structure, Quaternary
Crystallography, X-Ray

Related Papers

Paper Details
References
  • References25
  • Citations18
123
  • References25
  • Citations18
12
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