NAD dependent 11beta-hydroxysteroid dehydrogenase activity in human endometrium and endometrial tumors

Gynecologic and Obstetric Investigation
Tsatsas ManolisOvadia Abulafia

Abstract

The isoforms of 11beta-hydroxysteroid dehydrogenase (11beta-HSD) types 1 and 2, regulated by ovarian steroids, catalyze the interconversion of glucocorticoids and their 11-keto metabolites. The role of these enzymes in malignancies of human endometrium is unknown. We compare NAD dependent 11beta-HSD (type 2) activity levels among normal human endometrium and endometrial carcinomas of differing grades and histologies. NAD dependent 11beta-HSD activity was determined in endometrial tissue obtained from patients undergoing hysterectomy for benign or malignant disease (endometroid, serous and carcinosarcomas). Student's t test was utilized with p < 0.05 considered significant. Data are presented as mean +/- SD. NAD dependent 11beta-HSD activity was present in all endometrial samples. The activities were 0.61+/- 0.27 in normal (n = 9), 0.43 +/- 0.29 in endometrioid endometrial carcinoma (n = 14), 0.50 +/- 0.26 in uterine serous carcinoma (n = 6) and 0.25 +/- 0.37 in carcinosarcomas (n = 9). NAD dependent 11beta-HSD activity was lower in the carcinosarcoma group as compared to normal endometrial tissue (p = 0.03). NAD dependent type 2 11beta-HSD activity was demonstrated in all normal and endometrial tumors. Enzyme activity in endome...Continue Reading

References

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Citations

Oct 10, 2006·Steroids·Sarah TemkinOvadia Abulafia
Oct 12, 2018·Molecular Carcinogenesis·Anna M Mancha-RamirezThomas J Slaga
Jan 14, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Anne E King, Hilary O D Critchley

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