NAD⁺ in aging, metabolism, and neurodegeneration

Science
Eric Verdin

Abstract

Nicotinamide adenine dinucleotide (NAD(+)) is a coenzyme found in all living cells. It serves both as a critical coenzyme for enzymes that fuel reduction-oxidation reactions, carrying electrons from one reaction to another, and as a cosubstrate for other enzymes such as the sirtuins and poly(adenosine diphosphate-ribose) polymerases. Cellular NAD(+) concentrations change during aging, and modulation of NAD(+) usage or production can prolong both health span and life span. Here we review factors that regulate NAD(+) and discuss how supplementation with NAD(+) precursors may represent a new therapeutic opportunity for aging and its associated disorders, particularly neurodegenerative diseases.

References

Feb 1, 1983·The Journal of Nutrition·C J Gross, L M Henderson
Jun 11, 1999·The Journal of Biological Chemistry·J C AméG de Murcia
Oct 24, 2001·Cell·H VaziriR A Weinberg
Feb 19, 2002·Oncogene·M Teresa ValenzuelaF Javier Oliver
Jan 1, 1989·The European Journal of Neuroscience·E R LunnS Gordon
Dec 3, 2002·Science·Blanka RoginaStewart Frankel
Jul 29, 2003·Aging Cell·Osvaldo Delbono
Nov 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Blanka Rogina, Stephen L Helfand
Jan 28, 2006·Cell·Raul MostoslavskyFrederick W Alt
May 30, 2006·Biochemical and Biophysical Research Communications·Pinar AksoyEduardo N Chini
Aug 29, 2006·Biochemical and Biophysical Research Communications·Pinar AksoyEduardo N Chini
Nov 7, 2006·Nature·Joseph A BaurDavid A Sinclair
Dec 13, 2006·Trends in Biochemical Sciences·Peter BelenkyCharles Brenner
Jun 23, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Maria Thereza P BarbosaEduardo Nunes Chini
Oct 10, 2007·Molecular and Cellular Biology·David B LombardBjoern Schwer
Nov 13, 2007·Aging Cell·Srinivas AyyadevaraRobert J Shmookler Reis
Jun 14, 2008·Genes & Development·Danica ChenLeonard Guarente
Dec 26, 2008·Trends in Endocrinology and Metabolism : TEM·Antje GartenWieland Kiess
Mar 17, 2009·Science·Yasukazu NakahataPaolo Sassone-Corsi
Mar 21, 2009·Science·Kathryn Moynihan RamseyJoseph Bass
May 28, 2009·Molecular and Cellular Biology·Senthilkumar B RajamohanMahesh P Gupta
Nov 6, 2009·American Journal of Physiology. Endocrinology and Metabolism·Sheila R CostfordSteven R Smith
Dec 17, 2009·Endocrine Reviews·Riekelt H HoutkooperJohan Auwerx
Jan 12, 2010·The Journal of Biological Chemistry·Michelle PacholecKay Ahn

❮ Previous
Next ❯

Citations

Jan 20, 2016·Science·Matt KaeberleinGeorge M Martin
Mar 10, 2016·Nature Reviews. Molecular Cell Biology·Evandro Fei FangVilhelm A Bohr
Apr 24, 2016·Biochemical and Biophysical Research Communications·Kazuko Takahashi-NikiHiroyoshi Ariga
May 11, 2016·Molecular Aspects of Medicine·Jose ViñaMari Carmen Gomez-Cabrera
May 25, 2016·Free Radical Biology & Medicine·Changhan LeePinchas Cohen
Jun 11, 2016·Trends in Biochemical Sciences·Shahaf PelegAxel Imhof
Jun 28, 2016·Maturitas·Alan R HipkissBarbora de Courten
Oct 21, 2016·Biochimica Et Biophysica Acta·Yue Yang, Anthony A Sauve
Aug 16, 2016·Cell·Carlos López-OtínGuido Kroemer
Aug 18, 2016·Seminars in Cell & Developmental Biology·Maryline Moulin, Ana Ferreiro
Aug 18, 2016·Journal of Experimental Botany·Yuan ShenDao-Xiu Zhou
Apr 12, 2016·The European Journal of Neuroscience·Biao ChangJiang Peng
Oct 19, 2016·Nature Chemical Biology·John JanetzkoSuzanne Walker
Oct 30, 2016·Frontiers in Cell and Developmental Biology·Iryna Bohovych, Oleh Khalimonchuk
Nov 8, 2016·Structure·Chris A BroseyJohn A Tainer
Nov 2, 2016·The Journal of Physical Chemistry. a·Edward Matthews, Caroline E H Dessent
Jul 9, 2016·Free Radical Biology & Medicine·Dmitry S Bilan, Vsevolod V Belousov
Mar 28, 2017·The British Journal of Nutrition·Malen Massot-CladeraMargarida Castell
Apr 7, 2017·The FEBS Journal·Luca PalazzoIvan Ahel
Jan 28, 2017·Current Opinion in Cell Biology·Anne Brunet, Thomas A Rando
May 27, 2017·Antioxidants & Redox Signaling·Mariana PeharMarcelo R Vargas
Jun 22, 2017·Antioxidants & Redox Signaling·Joshua P Fessel, William M Oldham
Sep 19, 2017·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Richard Bedlack, UNKNOWN ALSUntangled Group
Jan 9, 2018·Journal of the National Cancer Institute·Valentina AudritoSilvia Deaglio
Feb 16, 2018·The Journal of Clinical Investigation·Mehdi TouatSophie Postel-Vinay
Aug 11, 2017·International Journal of Molecular Sciences·Weili Xu, Anis Larbi
Mar 3, 2018·Communicative & Integrative Biology·Pete A WilliamsSimon W M John
Sep 7, 2017·Antioxidants & Redox Signaling·Alexey GolubevVadim N Gladyshev
Feb 17, 2018·Cell and Tissue Research·Katarina Kluckova, Daniel A Tennant
Apr 11, 2018·Antioxidants & Redox Signaling·Rodrigo Franco, Marcelo R Vargas
Apr 17, 2018·Acta Physiologica·B P Woodall, Å B Gustafsson
Jan 11, 2018·The Journal of Biological Chemistry·Trevor CroftSu-Ju Lin
Nov 25, 2016·Genes & Development·Jan A van der Knaap, C Peter Verrijzer
Nov 11, 2017·Journal of Huntington's Disease·Janet M Dubinsky
Jan 4, 2018·Nature Communications·Hitoshi WatanabeHiroshi Inoue
Jun 15, 2018·Clinical & Experimental Ophthalmology·Chelsea GuymerRobert J Casson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Aging & Diabetes

This feed focuses on the role of the aging process on developing diabetes.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.