Oct 3, 2019

NAD+ in Brain Aging and Neurodegenerative Disorders

Cell Metabolism
Sofie LautrupEvandro F Fang

Abstract

NAD+ is a pivotal metabolite involved in cellular bioenergetics, genomic stability, mitochondrial homeostasis, adaptive stress responses, and cell survival. Multiple NAD+-dependent enzymes are involved in synaptic plasticity and neuronal stress resistance. Here, we review emerging findings that reveal key roles for NAD+ and related metabolites in the adaptation of neurons to a wide range of physiological stressors and in counteracting processes in neurodegenerative diseases, such as those occurring in Alzheimer's, Parkinson's, and Huntington diseases, and amyotrophic lateral sclerosis. Advances in understanding the molecular and cellular mechanisms of NAD+-based neuronal resilience will lead to novel approaches for facilitating healthy brain aging and for the treatment of a range of neurological disorders.

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Mentioned in this Paper

Neurons
Brain
Genomic Stability
Nerve Degeneration
Alzheimer's Disease
Amyotrophic Lateral Sclerosis
Mitochondrial Calcium Ion Homeostasis
Neuronal Plasticity
Adaptation
Neuronal

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