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NAD+ in Brain Aging and Neurodegenerative Disorders

Cell Metabolism

Oct 1, 2019

Sofie LautrupEvandro F Fang

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Abstract

NAD+ is a pivotal metabolite involved in cellular bioenergetics, genomic stability, mitochondrial homeostasis, adaptive stress responses, and cell survival. Multiple NAD+-dependent enzymes are involved in synaptic plasticity and neuronal stress resistance. Here, we review emerging findi...read more

Mentioned in this Paper

Aging
Alzheimer's Disease
Amyotrophic Lateral Sclerosis
Bioenergetics
Brain
Cell Survival
Huntington Disease
Nicotinamide adenine dinucleotide (NAD)
Nerve Degeneration
Nervous System Disorder
112
1
51
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NAD+ in Brain Aging and Neurodegenerative Disorders

Cell Metabolism

Oct 1, 2019

Sofie LautrupEvandro F Fang

PMID: 31577933

DOI: 10.1016/j.cmet.2019.09.001

Abstract

NAD+ is a pivotal metabolite involved in cellular bioenergetics, genomic stability, mitochondrial homeostasis, adaptive stress responses, and cell survival. Multiple NAD+-dependent enzymes are involved in synaptic plasticity and neuronal stress resistance. Here, we review emerging findi...read more

Mentioned in this Paper

Aging
Alzheimer's Disease
Amyotrophic Lateral Sclerosis
Bioenergetics
Brain
112
1
51

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