PMID: 8587795Jan 1, 1996Paper

NADPH diaphorase activity in peptidergic neurones of the parasitic nematode, Ascaris suum

Parasitology
Z A BascalR J Walker

Abstract

The histochemical marker for nitric oxide synthase, NADPH diaphorase, is known to co-localize in mammalian neurones with various classical neurotransmitters and neuropeptides. The nervous system of the parasitic nematode Ascaris suum has previously been shown to contain both NADPH diaphorase activity and neuropeptide immunoreactivity. This study examined the possibility that NADPH diaphorase and neuropeptide immunoreactivity may co-exist in the same neurones. Two antisera were used, one raised to KYSALMFamide, a C-terminal synthetic analogue of SALMFamide 1 (GFNSALMFamide), and another that recognizes calcitonin-gene-related peptide (CGRP). We provide evidence that in a distinct subset of neurones in the ventral, dorsal and lateral ganglia NADPH diaphorase staining and SALMFamide-like immunoreactivity are co-localized, suggesting a possible role for nitric oxide in modulating neuropeptide activity in these regions. CGRP-like immunoreactivity was less widely distributed, and was not consistently co-localized with NADPH diaphorase.

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Citations

Oct 14, 2003·Experimental Parasitology·María Elena Hernández-CamposIgnacio Valencia-Hernández
Feb 16, 2000·Experimental Parasitology·K M Pfarr, J A Fuhrman
Feb 17, 2000·Annals of the New York Academy of Sciences·T G GearyD P Thompson
Mar 7, 2007·Parasitology Research·Saúl Rojas-HernándezRafael Campos-Rodríguez
Nov 25, 2004·Experimental Cell Research·Laurent SégalatJudy E Anderson
Mar 4, 1998·Journal of Neurobiology·N L ScholzJ W Truman
Mar 24, 1999·Trends in Neurosciences·D J Brownlee, I Fairweather

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