PMID: 7542293Apr 8, 1995Paper

NADPH-diaphorase-positive nerve fibers in smooth muscle layers of opossum esophagus: gradients in density

Journal of the Autonomic Nervous System
J ChristensenG A Rick

Abstract

Nitric-oxide-releasing nerves regulate esophageal smooth muscle function. The density of such nerve fibers may differ in the different functional parts of the esophagus. We used both inspection and gray-scale analysis of digitized images to seek differences in density of such nerve fibers, stained for reduced nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-diaphorase), between esophageal body and esophago-gastric sphincter and between smooth muscle layers in the opossum esophagus. Sections of Swiss roll preparations of the entire organ were stained for NADPH-diaphorase and for immunoreactivity to vasoactive intestinal polypeptide (VIP), calcitonin gene-related peptide (CGRP), galanin (GAL), substance P (SP) and constitutive nitric oxide synthase (cNOS). In the circular muscle layer, NADPH-diaphorase-positive fibers were most abundant at the cephalic end of the esophageal body with a significant decline toward and through the esophago-gastric sphincter. In the longitudinal muscle layer and the longitudinally-oriented muscularis mucosae, NADPH-diaphorase-positive nerve fibers were most abundant at the esophago-gastric sphincter with a significant decline toward and through the striated-smooth muscle junction. cNOS i...Continue Reading

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Apr 15, 1991·The Journal of Comparative Neurology·Y AimiH Kimura
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Citations

Sep 29, 2001·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·X ZhangD A Sifrim
Sep 12, 2000·Current Gastroenterology Reports·H Park, J L Conklin
Dec 24, 1997·British Journal of Pharmacology·S Cellek, S Moncada
Feb 2, 2006·Cell and Tissue Research·Hirofumi Kuramoto, Makoto Kadowaki
Feb 6, 1998·The Journal of Laboratory and Clinical Medicine·J L Conklin
Sep 26, 2003·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J Christensen
Aug 29, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·W ShahinJ L Conklin
Nov 25, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Monika A KwiatekPeter J Kahrilas
Nov 3, 2015·Canadian Journal of Physiology and Pharmacology·Yong Zhang, William G Paterson
Aug 27, 2013·Gastroenterology·Peter J Kahrilas, Guy Boeckxstaens

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