NADPH metabolism: a survey of its theoretical characteristics and manipulation strategies in amino acid biosynthesis

Critical Reviews in Biotechnology
Jian-Zhong XuWei-Guo Zhang

Abstract

Reduced nicotinamide adenine nucleotide phosphate (NADPH), which is one of the key cofactors in the metabolic network, plays an important role in the biochemical reactions, and physiological function of amino acid-producing strains. The manipulation of NADPH availability and form is an efficient and easy method of redirecting the carbon flux to the amino acid biosynthesis in industrial strains. In this review, we survey the metabolic mode of NADPH. Furthermore, we summarize the research developments in the understanding of the relationship between NADPH metabolism and amino acid biosynthesis. Detailed strategies to manipulate NADPH availability are addressed based on this knowledge. Finally, the uses of NADPH manipulation strategies to enhance the metabolic function of amino acid-producing strains are discussed.

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Citations

Sep 24, 2019·Critical Reviews in Biotechnology·Fernanda Karine do Carmo FélixCarlos Ricardo Soccol
Apr 27, 2019·International Journal of Molecular Sciences·Ying-Yu WangLi-Ming Liu
May 20, 2020·Frontiers in Bioengineering and Biotechnology·Hai-Yan ZhouYu-Guo Zheng
Jan 31, 2020·Frontiers in Bioengineering and Biotechnology·Xiao-Yu WuBang-Ce Ye
Jul 28, 2020·World Journal of Microbiology & Biotechnology·Haozhe RuanJianzhong Xu
Apr 3, 2019·Journal of Industrial Microbiology & Biotechnology·Jian-Zhong XuWei-Guo Zhang
Mar 2, 2021·Frontiers in Cell and Developmental Biology·Na LiuYan Wang
Jul 4, 2019·Journal of Agricultural and Food Chemistry·Daqing Xu, Lirong Zhang
Sep 30, 2021·Journal of Agricultural and Food Chemistry·Anli WangYu Zhang
Nov 4, 2021·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Chuanzhou ZhangGuangfeng Kan
Nov 11, 2021·Chemistry : a European Journal·Zhongxian FanHuaiyi Huang
Jan 7, 2022·World Journal of Microbiology & Biotechnology·Shuai LiuWei-Guo Zhang

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