NADPH Oxidase 1 Is Associated with Altered Host Survival and T Cell Phenotypes after Influenza A Virus Infection in Mice

PloS One
Amelia R HofstetterShivaprakash Gangappa

Abstract

The role of the reactive oxygen species-producing NADPH oxidase family of enzymes in the pathology of influenza A virus infection remains enigmatic. Previous reports implicated NADPH oxidase 2 in influenza A virus-induced inflammation. In contrast, NADPH oxidase 1 (Nox1) was reported to decrease inflammation in mice within 7 days post-influenza A virus infection. However, the effect of NADPH oxidase 1 on lethality and adaptive immunity after influenza A virus challenge has not been explored. Here we report improved survival and decreased morbidity in mice with catalytically inactive NADPH oxidase 1 (Nox1*/Y) compared with controls after challenge with A/PR/8/34 influenza A virus. While changes in lung inflammation were not obvious between Nox1*/Y and control mice, we observed alterations in the T cell response to influenza A virus by day 15 post-infection, including increased interleukin-7 receptor-expressing virus-specific CD8+ T cells in lungs and draining lymph nodes of Nox1*/Y, and increased cytokine-producing T cells in lungs and spleen. Furthermore, a greater percentage of conventional and interstitial dendritic cells from Nox1*/Y draining lymph nodes expressed the co-stimulatory ligand CD40 within 6 days post-infection. ...Continue Reading

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Citations

Mar 7, 2018·Journal of Medical Microbiology·Seyit Ali BüyüktunaAynur Engin
Jul 28, 2018·Viruses·Olga A KhomichAlexander V Ivanov
Mar 27, 2020·MBio·Rebecca J MarshallKirsty R Short
Jul 22, 2020·BMC Microbiology·Ker-Kong ChenKazunari K Yokoyama
Apr 3, 2020·Antioxidants & Redox Signaling·Cassandra M Moshfegh, Adam J Case
Jun 30, 2021·Free Radical Biology & Medicine·Narjes Saheb Sharif-AskariRabih Halwani
Jul 4, 2021·The FEBS Journal·Zhen Wei Marcus TongKirsty R Short
Nov 16, 2021·The Journal of Clinical Investigation·Peter J SiskaKathrin Renner

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Methods Mentioned

BETA
flow cytometry
FACS
ELISA
bronchoalveolar lavage
genotyping
PCR
density gradient centrifugation
Assay

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