NADPH oxidase 4 expression in the normal endometrium and in endometrial cancer

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Christine DegasperAlain Gustave Zeimet

Abstract

The aim of this study was to explore the role of NOX4 in the biology of the normal endometrium and endometrial cancer. NOX4 plays a key role in other adenocarcinomas and has been implicated in the pathogenesis of diabetes and obesity, which are important risk factors for endometrial cancer. NOX4 expression was assessed in 239 endometrial cancer and 25 normal endometrium samples by quantitative real-time polymerase chain reaction, in situ hybridization, and immunohistochemistry. DNA methylation of the NOX4 promoter was determined by means of MethyLight PCR. Data were correlated with clinicopathological parameters and analyzed in the context of diabetes and body mass index. In the normal endometrium, NOX4 microRNA expression was significantly higher in the secretory transformed compared with proliferative endometrium ( p = 0.008). In endometrial cancer specimens, NOX4 expression did not differ between diabetic and non-diabetic patients, but was the highest in patients with a body mass index ≤ 26 ( p = 0.037). The lowest NOX4 expression was found in carcinosarcomas ( p = 0.007). High NOX4 expression predicted poorer clinical outcome with regard to overall survival, especially in non-diabetic patients and those with a body mass ind...Continue Reading

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Citations

Oct 28, 2019·Antioxidants & Redox Signaling·Prem Prakash KushwahaShashank Kumar
Apr 18, 2020·Carcinogenesis·Verena WieserHeidelinde Fiegl

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Methods Mentioned

BETA
hysterectomy
Assay
PCR

Software Mentioned

Primer Express
SPSS

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