NADPH oxidase activation in neutrophils: Role of the phosphorylation of its subunits

European Journal of Clinical Investigation
Sahra Amel BelambriJamel El-Benna

Abstract

Neutrophils are key cells of innate immunity and during inflammation. Upon activation, they produce large amounts of superoxide anion (O2-. ) and ensuing reactive oxygen species (ROS) to kill phagocytized microbes. The enzyme responsible for O2-. production is called the phagocyte NADPH oxidase. This is a multicomponent enzyme system that becomes active after assembly of four cytosolic proteins (p47phox , p67phox , p40phox and Rac2) with the transmembrane proteins (p22phox and gp91phox , which form the cytochrome b558 ). gp91phox represents the catalytic subunit of the NADPH oxidase and is also called NOX2. NADPH oxidase-derived ROS are essential for microbial killing and innate immunity; however, excessive ROS production induces tissue injury and prolonged inflammatory reactions that contribute to inflammatory diseases. Thus, NADPH oxidase activation must be tightly regulated in time and space to limit ROS production. NADPH oxidase activation is regulated by several processes such as phosphorylation of its components, exchange of GDP/GTP on Rac2 and binding of p47phox and p40phox to phospholipids. This review aims to provide new insights into the role of the phosphorylation of the NADPH oxidase components, that is gp91phox , p...Continue Reading

References

Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B D VolppR A Clark
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C A ParkosS H Orkin
Dec 1, 1994·Environmental Health Perspectives·B M Babior
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·T L LetoI de Mendez
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·H SumimotoK Takeshige
Jul 31, 1998·Clinical Science·A M CondliffeE R Chilvers
Jan 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·P M DangA Périanin
Jul 4, 2001·Nature Cell Biology·F KanaiM B Yaffe
Mar 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Pham My-Chan DangBernard M Babior
Nov 21, 2002·Cellular and Molecular Life Sciences : CMLS·P V Vignais
Jan 31, 2003·The Journal of Biological Chemistry·Robert V StahelinWonhwa Cho
Apr 4, 2003·Proceedings of the National Academy of Sciences of the United States of America·Tetsuro AgoHideki Sumimoto
May 7, 2003·Cell·Yvonne GroempingKatrin Rittinger
Jun 28, 2003·Blood·Fumitaka HayashiAndrew D Luster
Nov 14, 2003·Microbes and Infection·Dirk RoosChristof Meischl
Apr 23, 2004·The Journal of Biological Chemistry·Glenn E BrownMichael B Yaffe
Jul 6, 2004·The Biochemical Journal·Marie-Hélène PacletMarie-Claire Dagher
Dec 14, 2004·The Biochemical Journal·Yvonne Groemping, Katrin Rittinger
Aug 17, 2005·Blood Cells, Molecules & Diseases·Juan D MatutePablo J Patiño
Jun 17, 2006·The Journal of Clinical Investigation·Pham My-Chan DangJamel El-Benna
Sep 14, 2007·Immunological Reviews·William M Nauseef
Nov 26, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Houssam RaadJamel El-Benna
Apr 18, 2009·Experimental & Molecular Medicine·Jame El-BennaFrancoise Braut-Boucher
Sep 3, 2009·Journal of Structural Biology·Dominique DurandFranck Fieschi

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Citations

Oct 30, 2018·Journal of Leukocyte Biology·Erika RicciCarlo Riccardi
Feb 14, 2020·International Forum of Allergy & Rhinology·Kaili ZhengLuo Zhang
Feb 7, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jarmila KralovaTomas Brdicka
Jul 16, 2020·Journal of Clinical Immunology·Idit Lachover RothDavid Hagin
Aug 24, 2019·Frontiers in Molecular Neuroscience·Robin KoppAnnette Nicke
Aug 28, 2020·Frontiers in Cell and Developmental Biology·Yashaswini Seenappanahalli NanjundaiahMosharraf H Sarker
Oct 28, 2019·Frontiers in Immunology·Chih-Chao ChiangTsong-Long Hwang
Dec 25, 2019·Environmental Science and Pollution Research International·Karolina NowakWioletta Ratajczak-Wrona
Mar 3, 2020·Frontiers in Immunology·Patrizia BonsignoreChristof R Hauck
May 30, 2019·Frontiers in Immunology·Giacomo EmmiClaudia Fiorillo
Nov 5, 2020·International Journal of Molecular Sciences·Alexander I KostyukDmitry S Bilan
Feb 16, 2021·Moscow University Biological Sciences Bulletin·N V Vorobjeva
Feb 12, 2021·International Journal of Molecular Sciences·David Alexander Christian MessererMarkus Huber-Lang
Feb 13, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jiahui HanXiaoli Peng
Mar 7, 2021·International Journal of Molecular Sciences·Subroto ChatterjeeWendy Li
Mar 13, 2021·Cellular & Molecular Immunology·Dan LiuYali Hu
Mar 27, 2021·Current Opinion in Biotechnology·Stefan SchusterChristoph Kaleta
Mar 30, 2021·Frontiers in Cellular and Infection Microbiology·Qingsong JiangMingyun Li
Oct 5, 2020·Free Radical Biology & Medicine·Razieh RabaniWilliam S Powell
Apr 13, 2021·Frontiers in Cell and Developmental Biology·Zohreh Mansoori MoghadamJulia Kolter
Apr 25, 2021·Bulletin of Experimental Biology and Medicine·E V MikhalchikV I Sergienko
May 26, 2021·Journal of Fish Diseases·José Carlos Campos-SánchezMaría Ángeles Esteban

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