NADPH oxidase as an important source of reactive oxygen species at the mouse maternal-fetal interface: putative biological roles

Reproductive Biomedicine Online
Estela BevilacquaAndrea M Amarante-Paffaro

Abstract

Oxygen derivatives that comprise the large family of reactive oxygen species (ROS) are actively involved in placental biology. They are generated at the maternal-fetal interface at the level of decidual, trophoblast and mesenchymal components. In normal conditions, ROS produced in low concentrations participate in different functions as signalling molecules, regulating activation of redox-sensitive transcription factors and protein kinases involved in cell survival, proliferation and apoptosis, hence much of cell functioning. Physiological ROS generation is also associated with such defence mechanisms as phagocytosis and microbiocidal activities. In mice, particularly but not exclusively, trophoblast cells phagocytose intensively during implantation and post-implantation periods and express enzymic machinery to address a ROS-producing response to changes in the environment. The cells directly associated with ROS production are trophoblast giant cells, which mediate each and every relationship with the maternal organism. In this review, the production of ROS by the implanting mouse trophoblast is discussed, focusing on NADPH oxidase expression, regulatory mechanisms and similarities with NOX2 from phagocytes. Some of the current...Continue Reading

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Citations

Jun 3, 2014·Oxidative Medicine and Cellular Longevity·Liang-Jun Yan
May 15, 2012·Reproductive Biomedicine Online·Rosalind John, Myriam Hemberger
Apr 7, 2015·Free Radical Biology & Medicine·James N CobleyGraeme L Close
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Nov 10, 2020·Journal of Dietary Supplements·Sreus A G NaiduA Satyanarayan Naidu
Jun 3, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Olivia K TravisDenise C Cornelius

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