NADPH oxidase inhibition reduces tubular sodium transport and improves kidney oxygenation in diabetes.

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Patrik PerssonFredrik Palm

Abstract

Sustained hyperglycemia is associated with increased oxidative stress resulting in decreased intrarenal oxygen tension (Po(2)) due to increased oxygen consumption (Qo(2)). Chronic blockade of the main superoxide radicals producing system, the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, normalizes Qo(2) by isolated proximal tubular cells (PTC) and reduces proteinuria in diabetes. The aim was to investigate the effects of acute NADPH oxidase inhibition on tubular Na(+) transport and kidney Po(2) in vivo. Glomerular filtration rate (GFR), renal blood flow (RBF), filtration fraction (FF), Na(+) excretion, fractional Li(+) excretion, and intrarenal Po(2) was measured in control and streptozotocin-diabetic rats during baseline and after acute NADPH oxidase inhibition using apocynin. The effects on tubular transporters were investigated using freshly isolated PTC. GFR was increased in diabetics compared with controls (2.2 ± 0.3 vs. 1.4 ± 0.1 ml·min(-1)·kidney(-1)). RBF was similar in both groups, resulting in increased FF in diabetics. Po(2) was reduced in cortex and medulla in diabetic kidneys compared with controls (34.4 ± 0.7 vs. 42.5 ± 1.2 mmHg and 15.7 ± 1.2 vs. 25.5 ± 2.3 mmHg, respectively). Na(+) excretion was...Continue Reading

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Citations

Nov 28, 2012·Clinical and Experimental Pharmacology & Physiology·Peter HansellFredrik Palm
Feb 26, 2016·Antioxidants & Redox Signaling·Jay C JhaKarin A Jandeleit-Dahm
Oct 26, 2013·Journal of Receptor and Signal Transduction Research·Song Mao, Songming Huang
Oct 16, 2015·Experimental Biology and Medicine·Sarika Chaudhari, Rong Ma
Mar 24, 2017·Antioxidants·Agustin Gonzalez-Vicente, Jeffrey L Garvin
Sep 25, 2017·Diabetologia·Haiyun QiChristoffer Laustsen
Jan 17, 2019·American Journal of Physiology. Renal Physiology·Julie O'NeillKen D O'Halloran
Jun 20, 2019·American Journal of Physiology. Renal Physiology·Agustin Gonzalez-VicenteJeffrey L Garvin
Jan 17, 2014·American Journal of Physiology. Renal Physiology·Roger G EvansPaul M O'Connor
Nov 3, 2017·American Journal of Physiology. Renal Physiology·Stephanie FranzénFredrik Palm
Nov 26, 2019·American Journal of Physiology. Renal Physiology·Nianxin YangJeffrey L Garvin
Jan 31, 2020·Physiological Reviews·Jens Leipziger, Helle Praetorius
Sep 12, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Connie P C OwRoger G Evans
Feb 5, 2015·American Journal of Physiology. Renal Physiology·Brendan C FryAnita T Layton
Feb 7, 2019·The Pharmacogenomics Journal·Santiago CuevasPedro A Jose

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