NAFLD and Atherosclerosis Are Prevented by a Natural Dietary Supplement Containing Curcumin, Silymarin, Guggul, Chlorogenic Acid and Inulin in Mice Fed a High-Fat Diet

Nutrients
Antonella AmatoMarta Di Carlo

Abstract

Non-alcoholic fatty liver disease (NAFLD) confers an increased risk of cardiovascular diseases. NAFDL is associated with atherogenic dyslipidemia, inflammation and renin-angiotensin system (RAS) imbalance, which in turn lead to atherosclerotic lesions. In the present study, the impact of a natural dietary supplement (NDS) containingCurcuma longa, silymarin, guggul, chlorogenic acid and inulin on NAFLD and atherosclerosis was evaluated, and the mechanism of action was examined. C57BL/6 mice were fed an HFD for 16 weeks; half of the mice were simultaneously treated with a daily oral administration (os) of the NDS. NAFLD and atherogenic lesions in aorta and carotid artery (histological analysis), hepatic expression of genes involved in the NAFLD (PCR array), hepatic angiotensinogen (AGT) and AT₁R mRNA expression (real-time PCR) and plasma angiotensin (ANG)-II levels (ELISA) were evaluated. In the NDS group, steatosis, aortic lesions or carotid artery thickening was not observed. PCR array showed upregulation of some genes involved in lipid metabolism and anti-inflammatory activity (Cpt2, Ifng) and downregulation of some genes involved in pro-inflammatory response and in free fatty acid up-take (Fabp5, Socs3). Hepatic AGT, AT₁R mRN...Continue Reading

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Citations

May 8, 2018·Journal of the Science of Food and Agriculture·Maryam VahabzadehGholamreza Karimi
Aug 15, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Valentina Kaden-VolynetsStephan C Bischoff
Jan 16, 2020·International Journal of Molecular Sciences·Simona TerzoAntonella Amato
Aug 17, 2018·Nutrients·Giuseppe Grosso
Oct 13, 2018·Nutrients·Kenichiro TakanoToshisuke Morita
Apr 28, 2020·Current Medical Science·Wan-Yu LiuJian-Geng Huang
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Nov 20, 2020·Food & Function·M Maria LeenaC Anandharamakrishnan
Dec 3, 2020·Journal of Agricultural and Food Chemistry·Zhen-Dong YaoGang Zhao
Aug 30, 2021·Journal of Diabetes and Its Complications·Simona TerzoFlavia Mulè

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Methods Mentioned

BETA
PCR
ELISA

Software Mentioned

Graph Pad
Prism

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