nagie oko, encoding a MAGUK-family protein, is essential for cellular patterning of the retina

Nature Genetics
Xiangyun Wei, Jarema J Malicki


A layered organization of cells is a common architectural feature of many neuronal formations. Mutations of the zebrafish gene nagie oko (nok) produce a severe disruption of retinal architecture, indicating a key role for this locus in neuronal patterning. We show that nok encodes a membrane-associated guanylate kinase-family scaffolding protein. Nok localizes to the vicinity of junctional complexes in retinal neuroepithelium and in the photoreceptor cell layer. Mosaic analysis indicates that the nok retinal patterning phenotype is not cell-autonomous. We propose that nok function in patterning of postmitotic neurons is mediated through neuroepithelial cells and is necessary for guiding neurons to their proper destinations in retinal laminae.


Feb 18, 2011·Pflügers Archiv : European journal of physiology·Bayram EdemirThomas Weide
Sep 28, 2013·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Jian ZouXiangyun Wei
Jan 1, 2003·Methods : a Companion to Methods in Enzymology·Jarema J MalickiZac Pujic
Jan 14, 2003·Seminars in Cell & Developmental Biology·P Goldsmith, William A Harris
Jul 17, 2007·Nature Cell Biology·Michel BagnatDidier Stainier
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jingjing ZhangSalim Abdelilah-Seyfried
Aug 12, 2008·Stem Cells and Development·Eleonora M LadM Yashar S Kalani
Feb 6, 2008·Zebrafish·Peter F Hitchcock, Pamela A Raymond
Jun 15, 2006·Annual Review of Cell and Developmental Biology·Kunyoo ShinB Margolis
Jan 14, 2011·American Journal of Physiology. Renal Physiology·Jay Pieczynski, B Margolis
Jul 16, 2011·BMC Developmental Biology·Monica R HensleyYuk Fai Leung
Dec 7, 2006·Neural Development·Flavio R ZolessiWilliam A Harris
Jul 2, 2009·Journal of Cell Science·Kyra CampbellHelen Skaer
Feb 14, 2013·PloS One·Liyun ZhangYuk Fai Leung
Sep 18, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xiaojun YangXiangyun Wei
Feb 11, 2014·Progress in Retinal and Eye Research·Celso Henrique AlvesJan Wijnholds
Sep 15, 2012·Annual Review of Genetics·David Staudt, Didier Stainier
Mar 24, 2004·Seminars in Cell & Developmental Biology·Zac Pujic, Jarema J Malicki
Dec 17, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jian ZouXiangyun Wei
Aug 27, 2004·Médecine sciences : M/S·Céline LemmersAndré Le Bivic
Mar 6, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Bettina ErdmannMargret I Moré
Oct 5, 2007·Kidney International·Q Wang, B Margolis
Jun 19, 2012·Differentiation; Research in Biological Diversity·Shu Tu, Neil C Chi
May 23, 2012·European Journal of Cell Biology·Monalisa MishraElisabeth Knust
Apr 15, 2008·Experimental Eye Research·Ilse GosensRonald Roepman
Apr 1, 2008·Progress in Retinal and Eye Research·Lucia Galli-RestaElena Novelli
Oct 9, 2007·Experimental Cell Research·Ilse GosensRonald Roepman
Jan 16, 2007·Molecular and Cellular Neurosciences·Shuang CuiBrian A Link
Jul 8, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Breandán Kennedy, Jarema J Malicki
Dec 4, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Laura Anne LoweryHazel Sive
Nov 28, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Satish S Kitambi, Jarema J Malicki
Aug 21, 2007·Glia·Serge A van de PavertJan Wijnholds
Mar 11, 2009·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Laura Anne Lowery, Hazel Sive
Mar 8, 2006·The FEBS Journal·Albena KantardzhievaJan Wijnholds


Feb 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·D J StumpoP J Blackshear
Apr 16, 1998·Nature Genetics·E W KnapikH J Jacob
Jul 24, 1998·Molecular and Cellular Neurosciences·A ChennS K McConnell
Sep 22, 1998·Current Biology : CB·E Georges-LabouesseA Gansmüller
Jan 19, 1999·Methods in Cell Biology·Jarema J Malicki
Oct 12, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S D DimitratosP J Bryant
Feb 7, 2001·The Journal of Biological Chemistry·E KamberovB Margolis
Feb 7, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·H A Müller
Oct 4, 2000·Nature Genetics·A Nasevicius, S C Ekker

Related Concepts

Anatomical Layer
Complex (molecular entity)
Retinal Diseases
Lamiinae (invertebrate)
Scaffold protein
Cell Differentiation Process

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.