Nail fold videocapillaroscopy in mixed cryoglobulinaemia

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Daniela RossiDario Roccatello

Abstract

Nail fold videocapillaroscopy (NVC) has been extensively used to examine morphological and functional changes of microcirculation in connective tissue diseases. The nutritional circulation that depends on tissue capillaries, can be expected to be significantly impacted in mixed cryoglobulinaemia (MC). Using NVC, we evaluated 29 patients with MC (19 women), mean age 66 years (range 40-83). They included 28 hepatitis C virus (HCV) positive patients-14 genotype 1b, 10 genotype 2a 2c, two genotype 4, two with undetermined genotype. Of them, 18 had type II (IgMk-IgG) MC and 11 had type III. All patients were symptomatic, presenting with weakness (24 of 29 patients), arthralgia (24), purpura (16), peripheral neuropathy (20), Raynaud's phenomenon (8), hypertension (19) and membranoproliferative glomerulonephritis (MPGN) (9). The nail fold capillaries of four fingers per hand were examined using a videomicroscope. Of the 29 patients, 27 had morphological abnormalities (including tortuosity and apical enlargement), 18 had capillaries with deeply altered orientations, 17 had shortened capillaries and 20 neoangiogenetic phenomena. These four types of capillary abnormalities were simultaneously present in 10, suggesting this combination to...Continue Reading

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Citations

Jun 9, 2005·Best Practice & Research. Clinical Rheumatology·Maurizio CutoloAlberto Sulli
Jun 13, 2014·Blood Transfusion = Trasfusione Del Sangue·Simone BaldovinoDario Roccatello
Aug 10, 2010·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Yasser Sakr
Apr 13, 2010·Burns : Journal of the International Society for Burn Injuries·Ezio Nicola GangemiMaurizio Stella
Oct 10, 2008·Advances in Medical Sciences·F GallucciG Uomo
Dec 11, 2007·Best Practice & Research. Clinical Rheumatology·Maurizio CutoloCarmen Pizzorni
Dec 12, 2012·Autoimmunity Reviews·Daniela RossiDario Roccatello
Dec 23, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Dario RoccatelloMaria Ida Quarenghi
Aug 26, 2009·The International Journal of Lower Extremity Wounds·Gerit Mulder, Daniel K Lee
Feb 28, 2009·Arthritis and Rheumatism·Rossella De AngelisMaurizio Cutolo
Jan 6, 2019·Clinical Rheumatology·Chiara BertolazziMarwin Gutierrez

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