Nail psoriasis: a combined treatment with 8% clobetasol nail lacquer and tacalcitol ointment

Journal of the European Academy of Dermatology and Venereology : JEADV
M Sánchez RegañaPablo Umbert Millet

Abstract

Nail involvement is a common and distressing feature in the course of psoriasis. Although much progress has been made in the treatment of the disease, the presence of psoriasis in the nail continues to pose a challenge. In recent years, vitamin D3 analogs and a new formulation containing 8% clobetasol-17-propionate in a colourless nail lacquer vehicle have produced good results for the control of nail psoriasis. To determine the efficacy and safety of the combined treatment of 8% clobetasol-17-propionate in a lacquer vehicle and tacalcitol ointment in nail psoriasis. Fifteen patients with both nail bed and nail matrix psoriasis were included in the study. They were treated with a colourless nail lacquer containing 8% clobetasol-17-propionate applied at bedtime at the weekend, and with tacalcitol ointment under occlusion on the remaining days, for 6 months. All 15 patients responded well to treatment. The therapeutic effect was very fast and directly related to the length of therapy. All nail alterations, including nail pain, were reduced, and the modified target Nail Psoriasis Severity Index fell by an average of 78% compared to baseline levels (+/-59.6, P < 0.0001). Combined treatment with tacalcitol ointment and 8% clobetasol...Continue Reading

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Citations

Nov 17, 2010·Indian Journal of Dermatology, Venereology and Leprology·Sanjeev Handa
Jun 14, 2013·Dermatology Research and Practice·Yasemin Oram, A Deniz Akkaya
Jul 30, 2014·Indian Journal of Dermatology·Alka Dogra, Amanjot Kaur Arora
Oct 8, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·D RigopoulosD Ioannides
Apr 5, 2016·Drugs·Marcel C Pasch
Jul 24, 2012·Actas dermo-sifiliográficas·M Sánchez-RegañaP Umbert-Millet
May 10, 2012·Anais Brasileiros De Dermatologia·Robertha Carvalho NakamuraAndreia Pizarro Leverone
Apr 3, 2020·International Journal of Dermatology·Purva Thatai, Arshad B Khan
Apr 30, 2017·AAPS PharmSciTech·Avadhesh Singh KushwahaS Narasimha Murthy
Jun 4, 2021·Advances in Medical Sciences·Magdalena Acewicz, Irena Kasacka
Sep 4, 2021·Clinical Reviews in Allergy & Immunology·Chao JiBo Cheng

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