Naive and memory T cell subsets are differentially mobilized during physical stress

International Journal of Sports Medicine
G GannonR J Shephard

Abstract

This study examined the naive and memory phenotypic profiles of CD4+ and CD8hi T cells that were mobilized to the peripheral circulation during a combination of aerobic exercise and heat stress, determining expression of the adhesion molecules CD62L and CD11a on the recruited cells. Twelve recreationally active males (age 27.1 +/- 5.3 yr, height 1.77 +/- 0.08 m, mass 76.9 +/- 12.0 kg, VO2peak 43.9 +/- 6.7 mL x kg(-1) x min(-1)) completed a 40 min bout of cycle ergometry at 65 % of VO2peak while immersed to mid-chest in a water bath at 39 degrees C. Venous blood samples were collected before (T0), during (T40) and 30 min after (T70) exposure to combined exercise and heat stress. Specimens were analyzed by three-colour flow cytometry for CD4+ and CD8hi T cell expression of CD45RO, CD11a and CD62L. Some 80 % of the CD4+ T cells that were mobilized were of the CD45RO memory phenotype, with the numbers of CD11alo and CD62L+ cells increasing more than those of CD11ahi and CD62L- cells. For the CD8hi cells, there was a more equal recruitment of CD45RO- naive (43 %) and CD45RO+ memory (57 %) cells. The majority (84 %) of recruited CD8+ cells were CD11ahi; there was a trend to predominance of CD62L- cells (57 %) for the memory subset, b...Continue Reading

Citations

Aug 30, 2003·Brain, Behavior, and Immunity·J A WoodsQ Lu
Jun 24, 2010·The Proceedings of the Nutrition Society·J RomeoA Marcos
Sep 24, 2005·The British Journal of Nutrition·Ruud AlbersBernhard Watzl
Oct 4, 2007·Brain, Behavior, and Immunity·K KrügerF C Mooren
Mar 30, 2007·The Veterinary Journal·Fulvio RiondatoRoberta Guglielmino
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Feb 17, 2007·Journal of Applied Physiology·Michael Gleeson
Jan 23, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·G A SelkirkS G Rhind

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