Nalbuphine and butorphanol reverse opioid-induced respiratory depression but increase arousal in etorphine-immobilized goats (Capra hircus)

Veterinary Anaesthesia and Analgesia
Anna HawAndrea Fuller

Abstract

To evaluate and compare the efficacy of two opioid agonist-antagonists, nalbuphine and butorphanol, in reversing etorphine-induced respiratory depression in immobilized goats. Prospective, crossover, experimental trial conducted at 1753 m.a.s.l. Eight adult female Boer goats (Capra hircus). Eight minutes following immobilization with an intramuscular injection of 0.1 mg kg(-1) etorphine, goats were given one of nalbuphine (0.8 mg kg(-1) ), butorphanol (0.1 mg kg(-1) ) or sterile water intravenously, in random order in three trials. Respiratory rate (fR ), ventilation, tidal volume, oxygen consumption (V˙O2 ) and carbon dioxide production (V˙CO2 ) were measured continuously. Arterial blood samples to determine PaO2 and PaCO2 were taken 2 minutes before and at 5 minute intervals after etorphine administration for 25 minutes. Both nalbuphine and butorphanol increased mean PaO2 from 44 mmHg (5.9 kPa) to 63 mmHg (8.4 kPa) after etorphine administration. Butorphanol, but not nalbuphine, also corrected hypopnea and hypoventilation such that fR increased from 13 ± 4 to 21 ± 7 breaths minute(-1) (compared with 16 ± 6 breaths minute(-1) following nalbuphine) and ventilation increased from 4.69 ± 3.04 to 6.91 ± 4.42 L minute(-1) following...Continue Reading

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Citations

Aug 23, 2017·Journal of the South African Veterinary Association·Gareth E Zeiler, Leith C R Meyer
Feb 16, 2021·Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere·Claudia GittelAlef Michaele
Oct 21, 2017·Veterinary Anaesthesia and Analgesia·Gareth E Zeiler, Leith C R Meyer
Dec 28, 2021·Anesthesiology·Rutger van der SchrierAlbert Dahan

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