Nalbuphine is effective in decreasing the rewarding effect induced by morphine in rats

Drug and Alcohol Dependence
Pao-Luh TaoEagle Yi-Kung Huang

Abstract

Nalbuphine, a kappa-opioid agonist and mu-opioid partial agonist, has been widely used as an analgesic or an adjuvant with morphine in clinics. In rats, it attenuates tolerance and physical dependence caused by morphine, when co-administered. In this study, we investigated the effect of nalbuphine on morphine reward. Using the conditioned place preference (CPP) paradigm in rats, we demonstrated that co-administration of nalbuphine (1mg/kg, i.p.) with morphine (5mg/kg, i.p.) during conditioning could completely block the CPP induced by morphine. However, in experiments examining locomotor activity in rats, nalbuphine showed no effect on the development of behavioral sensitization induced by reported morphine administration. In microdialysis experiments, morphine induced a significant increase in the dopamine metabolites 3,4-dihydroxyphenylacetic acid and homovanillic acid in the shell region of the nucleus accumbens. Co-administration of nalbuphine blocked the increase in dopamine metabolites induced by morphine. These results may be due to the attenuating effect of nalbuphine on the dopaminergic activity of mesolimbic pathways. All of these results suggest nalbuphine could have a great potential as a pharmacotherapy for opiate ...Continue Reading

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Citations

May 3, 2012·Pain Research and Treatment·Richard H RechShannon L Briggs
Feb 8, 2014·Der Anaesthesist·A-M Schultz-MachataM Weiss
Oct 24, 2007·Peptides·Richard J Bodnar
Jul 28, 2019·British Journal of Pharmacology·Lucja KudlaRyszard Przewlocki
Sep 8, 2019·The Journal of Pharmacology and Experimental Therapeutics·Shane W KaskiVincent Setola
Dec 18, 2020·Anesthesia and Analgesia·Shane W KaskiDavid P Siderovski
Apr 10, 2021·Pharmacological Reports : PR·Lucja Kudla, Ryszard Przewlocki
Oct 13, 2018·Pharmacology, Biochemistry, and Behavior·Rahul RaghavPunit Kumar
May 21, 2021·The Journal of Pharmacology and Experimental Therapeutics·Beth YoungbloodNeil Schwartz

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