PMID: 8584201Aug 11, 1995Paper

Naloxone and initial estrogen action to induce lordosis in ovariectomized rats: the effect of a cut between the septum and preoptic area

Neuroscience Letters
M ToriiT Sasaki

Abstract

The effects of intra-third-ventricular (ITV) injection of naloxone (NLX), an opioid receptor antagonist, on lordosis behavior were studied in ovariectomized female rats given a horizontal half-circle cut located just above the anterior commissure (ARD) and subcutaneously (s.c.) treated with estradiol benzoate (EB) and progesterone (Prog). In ARD-sham control animals, lordosis quotient (LQ) was 78.8 +/- 4.2% (SE,n = 8). LQ (48.3 +/- 7.2%, SE, n = 8) in the ARD-sham rats significantly decreased with the ITV injection of NLX at the time of s.c. EB-priming. In contrast, lordosis reflex in the ARD-operated animals was maximally facilitated (sham versus ARD, P < 0.01). LQ in the ARD-operated rats did not decrease with the ITV injection of NLX at the s.c. EB-priming. The present results suggest that the opioidergic systems modulate an initial phase of estrogen action to induce lordosis and play a part in neural input from the forebrain structures to regulate female sexual receptivity.

References

Jul 1, 1988·Trends in Neurosciences·A MansourS J Watson
Jan 1, 1987·Neuroscience and Biobehavioral Reviews·J G Pfaus, B B Gorzalka
Sep 1, 1980·Canadian Journal of Physiology and Pharmacology·W H Moger

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Citations

Jan 1, 1996·Peptides·G A OlsonA J Kastin
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·Y S ZhuD W Pfaff
Apr 12, 2003·Pharmacology & Toxicology·Paul MicevychKevin Sinchak
May 26, 2004·Physiology & Behavior·Jill E Schneider
Sep 29, 2005·Neuroreport·Kevin SinchakPaul Micevych
Jun 24, 2017·Frontiers in Systems Neuroscience·Paul E Micevych, Robert L Meisel

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