PMID: 3748320Jul 1, 1986Paper

Naloxone antagonizes the hyperdipsic effect of sulpiride in a salt-preference test in male and female rats

Neuropharmacology
D B Gilbert, S J Cooper

Abstract

The consumption of saline and water in a two-bottle test of salt-preference was measured after the administration of sulpiride, a dopamine receptor antagonist and of naloxone, an antagonist at opiate receptors. The two drugs were injected alone, or in combination. Three concentrations of saline (0.125, 0.6 and 1.7% NaCl solutions) were used and the tests were carried out using both male and female, water-deprived rats. When the rats were allowed the choice between a highly-preferred 0.125% NaCl solution and water, sulpiride (30 mg kg-1, i.p.) produced an increase in the intake of the two fluids. When naloxone (1 mg kg-1, s.c.) was given alone, it had no effect in this test of salt preference, but when given in combination, completely eliminated the hyperdipsic effect of sulpiride, providing behavioural evidence of a significant interaction between sulpiride and naloxone. When choices of either 0.6 or 1.7% NaCl solutions and water were given, the baseline levels of the consumption of the fluids were increased. Under these circumstances, sulpiride did not significantly increase the consumption of fluids; instead, naloxone significantly reduced the level of fluid consumption. In a further experiment, apomorphine, at dose levels wh...Continue Reading

References

Jan 11, 1979·Nature·J W Kebabian, D B Calne
Oct 1, 1977·Pharmacology, Biochemistry, and Behavior·N Rowland, D J Engle
Dec 17, 1981·European Journal of Pharmacology·S Arbilla, S Z Langer
Jul 15, 1983·European Journal of Pharmacology·J Hyttel
Dec 3, 1984·Life Sciences·J C Stoof, J W Kebabian
Aug 3, 1984·European Journal of Pharmacology·A J GowerC L Broekkamp

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Citations

Aug 1, 1988·Pharmacology, Biochemistry, and Behavior·M A ParadaB G Hoebel
Nov 1, 1987·Peptides·G A OlsonA J Kastin
Apr 10, 2012·Physiology & Behavior·A I R NascimentoJ B Fregoneze
Feb 20, 1998·Appetite·M E Mercer, M D Holder

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