PMID: 11311731Apr 20, 2001Paper

Naloxone blocks 'anxiolytic' effects of neuropeptide Y

Peptides
K T Britton, S Southerland

Abstract

Intracerebroventricular injection of neuropeptide Y (NPY) produces potent 'anxiolytic' effects in animal models of anxiety. Administration of opioid receptor antagonists suppresses NPY-induced food intake and thermogenesis. The present study examined whether the opiate antagonist naloxone would also suppress the 'anxiolytic' effects of neuropeptide Y. Following training and stabilization of responding in an operant conflict model of anxiety, rats were injected with either NPY or diazepam. Both NPY (veh., 2, 4, 6 microg, i.c.v.) and chlordiazepoxide (veh., 2, 4, 6 mg/kg, i.p.) produced a dose-dependent increase in punished responding in the conflict test. The 'anxiolytic' effects of NPY were not blocked by the administration of flumazenil (3, 6, 12 mg/kg, i.p.). The administration of naloxone (0.25-2.0 mg/kg, s.c.) antagonized the effects of NPY. Central administration of the selective mu opiate antagonist CTAP (1 microg, i.c.v.) partially blocked NPY-induced conflict responding. These results support the hypothesis that NPY may play an important role in experimental anxiety independent of the benzodiazepine receptor and further implicate the opioid system in the behavioral expression of anxiety.

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Citations

Jul 22, 2004·Behavioural Brain Research·Cristina C CarvajalRémi Quirion
Jan 22, 2003·Peptides·Richard J Bodnar, Maria M Hadjimarkou
Mar 20, 2003·Bioorganic & Medicinal Chemistry Letters·James J KiddleSonia Soles
Sep 3, 2010·PloS One·Eszter D SchoellChristian Buechel
Jan 24, 2006·Peptides·Stefany D PrimeauxGeorge A Bray
Aug 18, 2020·Neuroscience Letters·Jun-Ichi ShiraishiTakashi Bungo

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