Naloxone regulates the differentiation of neural stem cells via a receptor-independent pathway.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Jinlong ChenHui Zheng

Abstract

The abilities of opioids to activate downstream signaling pathways normally depend on the binding between opioids and their receptors. However, opioids may also function in a receptor-independent manner, especially in neural stem cells (NSCs) in which the expression of opioid receptors and endogenous opioid agonists is low. When two opioids, morphine and naloxone, were used during the early stage of NSC differentiation, increased neurogenesis was observed. However, naloxone methiodide, a membrane impenetrable analog of naloxone, did not affect the NSC differentiation. The abilities of morphine and naloxone to facilitate neurogenesis were also observed in opioid receptor-knockout NSCs. Therefore, morphine and naloxone promote neurogenesis in a receptor-independent manner at least during the early stage. In addition, the receptor-independent functions of opioids were not observed in methylcytosine dioxygenase ten-eleven translocation 1 (Tet1) knockout NSCs. When the expression of opioid receptors increased and the expression of Tet1 decreased during the late stage of NSC differentiation, morphine, but not naloxone, inhibited neurogenesis via traditional receptor-dependent and miR181a-Prox1-Notch-related pathway. In summary, the c...Continue Reading

References

May 1, 1995·Anesthesiology·A Duttaroy, B C Yoburn
Aug 7, 1999·The Journal of Biological Chemistry·H C LiuH H Loh
Jun 7, 2000·Proceedings of the National Academy of Sciences of the United States of America·A J EischE J Nestler
Jul 3, 2003·Molecular and Cellular Neurosciences·Anders I PerssonPeter S Eriksson
Oct 12, 2004·Molecular Pharmacology·Thomas KochVolker Höllt
Jan 20, 2006·Hippocampus·Benedetta LeunerTracey J Shors
Apr 5, 2007·Nature Protocols·Stefanie Kaech, Gary Banker
Jul 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Hui ZhengPing-Yee Law
May 25, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nazia KhurshidSoumya Iyengar
Jun 18, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hui ZhengPing-Yee Law
Dec 20, 2011·BMC Bioinformatics·Davide RissoSandrine Dudoit
Apr 24, 2012·The Journal of Pain : Official Journal of the American Pain Society·Susannah S LewisLinda R Watkins
Jan 11, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hui ZhengPing-Yee Law
Jun 19, 2013·Cell Stem Cell·Run-Rui ZhangGuo-Liang Xu
Oct 29, 2013·Nature Genetics·Jiekai ChenDuanqing Pei
Apr 30, 2016·TheScientificWorldJournal·Yue ZhangPing-Yee Law
Apr 21, 2017·Nucleic Acids Research·Andrew P HutchinsDuanqing Pei
Dec 7, 2017·Cell Reports·Jing Liang, Michael J Krashes

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Citations

Oct 10, 2020·Nature Communications·Yinghua HuangBaoming Qin

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