PMID: 8939467Oct 25, 1996Paper

Naloxone reverses the inhibitory effect of gamma-hydroxybutyrate on central DA release in vivo in awake animals: a microdialysis study

Neuroscience Letters
J Feigenbaum, S G Howard

Abstract

gamma-Hydroxybutyrate (GHB) is a 4-carbon anesthetic that acts primarily by inhibiting presynaptic dopamine (DA) release in vivo. A number of studies have reported a reversal of many of the central effects of GHB by the allegedly pure opiate antagonist naloxone (NX) but its mechanism of action is unclear. In vivo microdialysis performed in the present preliminary study disclosed a significant inhibitory effect of GHB (500 mg/kg) on striatal DA release which was completely reversed by a low dose of NX (0.8 mg/kg). The results indicate that NX likely inhibits many of the central effects produced by GHB primarily through its reversal of the GHB induced inhibition of central DA release.

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Citations

Jul 13, 2000·Brain Research. Molecular Brain Research·M P CastelliG L Gessa
Jul 4, 2012·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Leo J SchepBruno Mégarbane
Aug 17, 2006·Acta Neurologica Scandinavica·K R DrasbekK Jensen
Sep 20, 2011·Journal of Psychopharmacology·Oliver G BoschThomas C Wetter
Aug 2, 2003·Annals of Neurology·C Guin Ting WongO Carter Snead
Jul 19, 1997·The Veterinary Record·J D McEvoy
Jan 8, 2016·Medicinal Research Reviews·Michel MaitreAyikoe G Mensah-Nyagan
Aug 10, 2004·Toxicological Reviews·C Guin Ting WongO Carter Snead

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