Naltrexone blocks the expression of the conditioned elevation of natural killer cell activity in BALB/c mice.

Brain, Behavior, and Immunity
H B SolvasonV K Ghanta

Abstract

An elevation of natural killer (NK) cell activity was conditioned by the association of a camphor odor conditioning stimulus (CS) with an injection of 20 micrograms polyinosinic:poly-cytidylic acid (poly I:C), the unconditioned stimulus (US). Poly I:C elicits the production and secretion of interferon (IFN), which induces an increase in NK cell activity. Reexposure to the CS occurred on Days 3 and 5 after the association trial on Day 0. Immediately following the CS exposure on Day 5, 1 microgram poly I:C was administered to all animals. This procedure resulted in an increased NK cell activity in the conditioned (CND), but not the nonconditioned (NC), mice. In this study we have shown that the expression of the conditioned response was blocked by an injection of naltrexone (NTX) at 10 mg/kg ip when given immediately prior to the two test CS odor exposures. Peripheral treatment (ip) with a quaternary form of naltrexone (QNTX), which is a less potent opiate antagonist, at the same dose and at the same time relative to the CS odor reexposure did not block the conditioned response. The formation of the conditioned association did not appear to be disrupted by NTX at the 10 mg/kg dose when given immediately prior to the trial odor ex...Continue Reading

References

Nov 1, 1979·Behavioral and Neural Biology·R B MessingJ L McGaugh
Jul 1, 1975·Psychosomatic Medicine·R Ader, N Cohen
Aug 1, 1987·Behavioral Neuroscience·M Vigorito, J J Ayres
Jul 1, 1987·Pharmacology, Biochemistry, and Behavior·D J CalcagnettiM S Fanselow
Jan 1, 1987·Journal of Neuroscience Research·H Besedovsky, A del Rey
Oct 1, 1987·Pharmacology, Biochemistry, and Behavior·A BecharaD van der Kooy
Dec 1, 1987·Immunological Reviews·D A Weigent, J E Blalock
Mar 1, 1985·Neuropharmacology·D R Brown, L I Goldberg
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·Y ShavitJ C Liebeskind
Jan 1, 1987·Physiology & Behavior·H V PeekeM Salfi
Jan 1, 1987·Journal of Neuroscience Research
Jan 1, 1984·Journal of Interferon Research·H MachidaY Watanabe
Sep 1, 1984·The Journal of Clinical Investigation·C A DinarelloF Coceani
Aug 12, 1983·Science·I S Zagon, P J McLaughlin

❮ Previous
Next ❯

Citations

Apr 24, 1992·Brain Research·C M HsuehV K Ghanta
Apr 24, 1995·Brain Research·C M HsuehR N Hiramoto
Oct 1, 1992·Pharmacology, Biochemistry, and Behavior·C RogersR Hiramoto
Feb 1, 1993·Pharmacology, Biochemistry, and Behavior·R N HiramotoV K Ghanta
Mar 1, 1995·Pharmacology, Biochemistry, and Behavior·V K GhantaR N Hiramoto
Aug 11, 2001·Journal of Neuroimmunology·J S KuoC M Hsueh
Jun 22, 1999·Journal of Neuroimmunology·C M HsuehR J Lin
Jul 1, 1993·The International Journal of Neuroscience·B M MarkovićB D Janković
Jul 1, 1993·The International Journal of Neuroscience·V K GhantaR N Hiramoto
Apr 2, 1998·The International Journal of Neuroscience·R N HiramotoV K Ghanta
Feb 1, 1996·The International Journal of Neuroscience·R HiramotoV Ghanta
Aug 8, 2007·Brain, Behavior, and Immunity·Jan A Moynihan, Félix M Santiago
Jul 8, 1999·The International Journal of Neuroscience·R N HiramotoV K Ghanta

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.