Naltrexone does not prevent acquisition or expression of flavor preferences conditioned by fructose in rats

Pharmacology, Biochemistry, and Behavior
Robert W BakerR J Bodnar

Abstract

The effects of the general opioid antagonist, naltrexone, on the acquisition and expression of flavor preferences conditioned by the sweet taste of fructose were examined. Food-restricted rats were trained over eight daily alternating one-bottle sessions (2 h) to drink an 8% fructose solution containing one novel flavor (CS+/F) and a less preferred 0.2% saccharin solution containing a different flavor (CS-/S). Four groups of rats were treated daily with either saline (control group) or naltrexone doses of 0.1, 1.0, or 5.0 mg/kg during training. Preferences were assessed in two-bottle tests with the CS+/S and CS-/S flavors presented in 0.2% saccharin solutions following saline injections. Naltrexone dose-dependently reduced fructose and saccharin intakes during training, confirming the drug's well-known suppressive effect on the intake of sweet solutions. Despite their reduced training intakes, the naltrexone groups displayed preferences for the CS+/S over the CS-/S (72-86%) that were similar to that of the control group (78%). The effect of naltrexone on the expression of the CS+/S flavor preference was evaluated by treating control rats with naltrexone (0.1-5 mg/kg) prior to CS+/S vs. CS-/S choice tests. The drug doses produce...Continue Reading

References

Aug 1, 1992·Alcoholism, Clinical and Experimental Research·K S Schwarz-StevensH H Samson
Nov 1, 1991·Physiology & Behavior·D J Shide, E M Blass
Mar 1, 1990·Physiology & Behavior·P A BreslinH J Grill
Apr 1, 1986·Pharmacology, Biochemistry, and Behavior·W C Lynch
Jan 1, 1987·Neuroscience and Biobehavioral Reviews·A Sclafani
May 1, 1980·Pharmacology, Biochemistry, and Behavior·J Le MagnenM Devos
Jan 1, 1982·Physiology & Behavior·A S LevineJ E Morley
Dec 1, 1982·Physiology & Behavior·G A Rockwood, L D Reid
Jan 1, 1995·Neuroscience and Biobehavioral Reviews·K C Berridge, S Peciña
Jan 1, 1996·Neuroscience and Biobehavioral Reviews·K C Berridge
Jul 16, 2002·Physiology & Behavior·A E KelleyM Zhang
Oct 12, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Allen S LevineCharles J Billington
Dec 14, 2002·Neuroscience and Biobehavioral Reviews·Martin R Yeomans, Richard W Gray
Jun 28, 2003·Nutrition Reviews·Takashi Yamamoto

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Citations

May 25, 2006·Behavioral Neuroscience·Michael E NizhnikovNorman E Spear
Feb 9, 2016·European Journal of Pharmacology·Francis M RotellaRichard J Bodnar
Oct 30, 2012·Neurobiology of Learning and Memory·J A D Dela CruzR J Bodnar
May 10, 2011·Physiology & Behavior·Anthony SclafaniRichard J Bodnar
Jul 27, 2010·Pharmacology, Biochemistry, and Behavior·Kristine B BonacchiAnthony Sclafani
Jul 21, 2010·Physiology & Behavior·Dominic M Dwyer, Mihaela D Iordanova
Jul 6, 2010·Pharmacology, Biochemistry, and Behavior·Khalid TouzaniAnthony Sclafani
Mar 24, 2009·Physiology & Behavior·Karen AckroffAnthony Sclafani
Aug 1, 2015·Journal of Nutritional Science and Vitaminology·Kazuhiro SakamotoTohru Fushiki
Jul 8, 2008·Physiology & Behavior·Kristine B BonacchiAnthony Sclafani
Apr 27, 2007·Pharmacology, Biochemistry, and Behavior·Clifford C Michaels, Stephen G Holtzman
Mar 14, 2007·Pharmacology, Biochemistry, and Behavior·Glen J Golden, Thomas A Houpt
Oct 4, 2005·The European Journal of Neuroscience·Khalid Touzani, Anthony Sclafani
Sep 8, 2007·The European Journal of Neuroscience·Khalid Touzani, Anthony Sclafani
Jul 26, 2005·Peptides·Richard J Bodnar, Gad E Klein
May 25, 2015·Physiology & Behavior·Anthony SclafaniKaren Ackroff
Dec 18, 2014·Bioscience, Biotechnology, and Biochemistry·Kazuhiro SakamotoTohru Fushiki
Oct 26, 2016·Pharmacology, Biochemistry, and Behavior·Francis M RotellaRichard J Bodnar

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